• A mathematical modelling study...

Treffer: A mathematical modelling study to investigate the effectiveness of supplementary immunization activities (SIAs) on controlling measles transmission in southern China

Title:
A mathematical modelling study to investigate the effectiveness of supplementary immunization activities (SIAs) on controlling measles transmission in southern China
Contributors:
Sun, Riyang (author.), Zee, Benny (thesis advisor.), Chinese University of Hong Kong Graduate School. Division of Public Health. (degree granting institution.)
Publication Year:
2018
Collection:
The Chinese University of Hong Kong: CUHK Digital Repository / 香港中文大學數碼典藏
Subject Terms:
Measles--Prevention--Mathematical models, Measles--China--Prevention--Mathematical models, Measles--Vaccination--Mathematical models, Measles--Vaccination--China--Mathematical models, Measles--prevention & control, Immunization Programs, Program Evaluation--methods, Models, Theoretical, China
Subject Geographic:
China
Document Type:
Fachzeitschrift text
File Description:
electronic resource; remote; 1 online resource (xii, 160 leaves) : illustrations (some color); computer; online resource
Language:
English
Chinese
Relation:
cuhk:2188051; local: ETD920200194; local: AAI13837889; local: 991039750405003407
Availability:
https://julac.hosted.exlibrisgroup.com/primo-explore/search?query=addsrcrid,exact,991039750405003407,AND&tab=default_tab&search_scope=All&vid=CUHK&mode=advanced&lang=en_US
https://repository.lib.cuhk.edu.hk/en/item/cuhk-2188051
Rights:
Use of this resource is governed by the terms and conditions of the Creative Commons "Attribution-NonCommercial-NoDerivatives 4.0 International" License (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Accession Number:
edsbas.EB10230D
Database:
BASE

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Ph.D. ; The World Health Organization (WHO) has set the goal of eliminating the measles in at least 5 WHO regions by 2020 and recommended the two dose measles containing vaccine (MCV) schedule coupled with supplementary immunization activity (SIA) to achieve the goal. The policy-makers are interested to know how to adjust the immunization strategies to eliminate the measles. China has been implementing a routine, two-dose schedule of MCV. Additionally, a national SIA has been implemented in 2010, targeting children between 8 months and 14 years old, to interrupt measles transmission. However, a resurgence has occurred in 2012. Yet, China is now facing multiple challenges due to the upward shifting of infection ages and immunity gap in adults. According to some research, the value of the SIA targeting adults was controversial; and regular catch-up or follow-up SIAs were limited in China. These problems largely motivated us to study the effectiveness of the outbreak-response immunization (ORI) on measles control among adults. In the body of thesis, we systematically reviewed the effectiveness of previous SIAs globally and studied the changes of epidemiological characteristics and reproductive numbers of measles in different age groups in Guangdong province from 2009 to 2016. Then the new mathematical model was developed by using daily number of measles cases in Guangdong province, southern China as a case study to explore the effect of ORI for adults in Guangdong. Our results showed that the single dose SIA had limited impact on controlling measles for long-term effect and few SIAs were targeting adults especially in China. After the implementation of large scale SIA in 2010 in China, the epidemiological characteristics and reproductive numbers in Guangdong have changed, infants aged 0-8 months had replaced the 7-25 years old in having most measles cases during the resurgence after 2012, and that adults aged 26 or above had an increasing proportion contributed after 2014. The ORI for adults was valuable on ...