• Early generation dynamic and s...

Treffer: Early generation dynamic and static proton arc treatment planning algorithms assessment in oropharyngeal cancer patients

Title:
Early generation dynamic and static proton arc treatment planning algorithms assessment in oropharyngeal cancer patients
Authors:
De Jong, Bas Adriaan, Zhao, Lewei, Liu, Peilin, Wase, Viktor, Marthin, Otte, Sundström, Johan, Liu, Gang, Deroniyagala, Rohan, Li, Xiaoqiang, Cong, Xiaoda, Janssens, Guillaume, Engwall, Erik, Korevaar, Erik W, Ding, Xuanfeng, Langendijk, Johannes Albertus, Both, Stefan
Source:
De Jong, B A, Zhao, L, Liu, P, Wase, V, Marthin, O, Sundström, J, Liu, G, Deroniyagala, R, Li, X, Cong, X, Janssens, G, Engwall, E, Korevaar, E W, Ding, X, Langendijk, J A & Both, S 2025, 'Early generation dynamic and static proton arc treatment planning algorithms assessment in oropharyngeal cancer patients', Medical Physics, vol. 52, no. 7, e17916. https://doi.org/10.1002/mp.17916
Publication Year:
2025
Collection:
University of Groningen research database
Subject Terms:
Humans, Radiotherapy Planning, Computer-Assisted/methods, Proton Therapy/adverse effects, Oropharyngeal Neoplasms/radiotherapy, Algorithms, Radiotherapy, Intensity-Modulated/methods, Radiotherapy Dosage, Organs at Risk/radiation effects
Document Type:
Fachzeitschrift article in journal/newspaper
File Description:
application/pdf
Language:
English
Relation:
info:eu-repo/semantics/altIdentifier/pmid/40660888; info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/11370/b1a8a819-6dd4-47c2-bc00-ae9d384b54eb; info:eu-repo/semantics/altIdentifier/pissn/0094-2405
DOI:
10.1002/mp.17916
Availability:
https://hdl.handle.net/11370/b1a8a819-6dd4-47c2-bc00-ae9d384b54eb
https://research.rug.nl/en/publications/b1a8a819-6dd4-47c2-bc00-ae9d384b54eb
https://doi.org/10.1002/mp.17916
https://pure.rug.nl/ws/files/1351771754/Medical_Physics_-_2025_-_De_Jong_-_Early_generation_dynamic_and_static_proton_arc_treatment_planning_algorithms_assessment.pdf
Rights:
info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/
Accession Number:
edsbas.88908867
Database:
BASE

Weitere Informationen

BACKGROUND: Compared with intensity modulated proton therapy (IMPT), proton arc treatment (PAT) employs an increased number of gantry angles, potentially reducing healthy tissues doses, especially for complex target geometries found in oropharyngeal cancer (OPC) treatment. PAT plans can be optimized with algorithms, based either on "static" gantry position or "dynamic" gantry movement during dose delivery. Recent results have shown target coverage may suffer more from inter-fraction patient anatomical- and setup changes In PAT than IMPT. PURPOSE: We assessed if PAT plans generated with one static and two dynamic PAT planning algorithms can improve expected plan toxicity, delivery time, and inter-fraction robustness compared to clinical volumetric modulated arc therapy (VMAT) and IMPT plans for OPC patients. METHODS: Six OPC patients were included that qualified for proton therapy based on model-based selection, with IMPT plans superior to the VMAT plans in terms of toxicities. Static PAT plans were produced using an energy layer filtration (ELF) algorithm, and dynamic PAT plans were produced with two different methods: (1) Spot scanning Proton Arc (SPArc), and (2) Early Layer and Spot Assignment (ELSA). Two sets of PAT plans with about 360 or 240 energy layers and an additional ELF plan employing anterior oblique range shifted fields were produced. All proton plans were robustly optimized. Expected plan toxicity was determined using normal tissue complication probability (NTCP) models for dysphagia and xerostomia. A delivery time model was calibrated using experimental machine log-files and gantry dynamics from an IBA Proteus PLUS system (IBA Ltd, Belgium). Inter-fraction robustness was evaluated on a fraction-wise (on weekly repeated CT) and course-wise (accumulated over all weekly repeated CTs) basis. RESULTS: All PAT strategies showed significantly (p-values < 0.05) reduced NTCPs for dysphagia and xerostomia grade ≥ 2 compared to IMPT and VMAT. Relative to VMAT, NTCP for xerostomia reduced by on average ...