• Molecular landscape of sex- an...

Treffer: Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration

Title:
Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration
Authors:
Jacques, Macsue, Landen, Shanie, Sharples, Adam P., Garnham, Andrew, Schittenhelm, Ralf, Steele, Joel, Heikkinen, Aino, Sillanpää, Elina, Ollikainen, Miina, Broatch, James, Zarekookandeh, Navabeh, Hanson, Ola, Ekström, Ola, Asplund, Olof, Lamon, Séverine, Alexander, Sarah E., Smith, Cassandra, Bauer, Carlie, Woessner, Mary N., Levinger, Itamar, Teschendorff, Andrew E., Gillberg, Linn, Blom, Ida, Helge, Jørn Wulff, Harvey, Nicholas R., Haupt, Larisa M., Griffiths, Lyn R., Deshmukh, Atul S., Pietiläinen, Kirsi H., Piirilä, Päivi, Seaborne, Robert A.E., Klevjer, Marie, Bye, Anja, Wisløff, Ulrik, Jones-Freeman, Bernadette, Eynon, Nir
Source:
Jacques, M, Landen, S, Sharples, A P, Garnham, A, Schittenhelm, R, Steele, J, Heikkinen, A, Sillanpää, E, Ollikainen, M, Broatch, J, Zarekookandeh, N, Hanson, O, Ekström, O, Asplund, O, Lamon, S, Alexander, S E, Smith, C, Bauer, C, Woessner, M N, Levinger, I, Teschendorff, A E, Gillberg, L, Blom, I, Helge, J W, Harvey, N R, Haupt, L M, Griffiths, L R, Deshmukh, A S, Pietiläinen, K H, Piirilä, P, Seaborne, R A E, Klevjer, M, Bye, A, Wisløff, U, Jones-Freeman, B & Eynon, N 2025, 'Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through ....
Publication Year:
2025
Collection:
King's College, London: Research Portal
Subject Terms:
Humans, Male, Muscle, Skeletal/metabolism, Female, Exercise/physiology, Adaptation, Physiological/genetics, DNA Methylation/genetics, Transcriptome/genetics, Adult, Oxygen Consumption, Middle Aged, Sex Characteristics, Proteome, Sex Factors, Multiomics
Document Type:
Fachzeitschrift article in journal/newspaper
File Description:
application/pdf
Language:
English
DOI:
10.1016/j.celrep.2025.115750
Availability:
https://kclpure.kcl.ac.uk/portal/en/publications/be14b227-69d8-4f49-9112-9ae18e9ada5e
https://doi.org/10.1016/j.celrep.2025.115750
https://kclpure.kcl.ac.uk/ws/files/337585976/1-s2.0-S2211124725005212-main.pdf
http://www.scopus.com/inward/record.url?scp=105006740608&partnerID=8YFLogxK
https://linkinghub.elsevier.com/retrieve/pii/S2211124725005212
Rights:
info:eu-repo/semantics/openAccess
Accession Number:
edsbas.87A1D52D
Database:
BASE

Weitere Informationen

We investigated the molecular mechanisms of exercise adaptations in human muscle by integrating genome, methylome, transcriptome, and proteome data from over 1,000 participants (2,340 muscle samples). We identified distinctive signatures associated with maximal oxygen consumption (VO 2max), and multi-omics integration uncovered five key genes as robust exercise markers across layers, with transcription factors functioning as activators, synergizing with DNA methylation to regulate gene expression. Minimal sex differences were observed, while modality-specific analysis highlighted distinct pathways for aerobic and resistance exercise, contrasting with muscle disuse patterns. Finally, we created a webtool, OMAx, featuring our individual omics and integration analysis. These findings provide a comprehensive multi-omics framework for understanding exercise-induced molecular adaptations, offering insights into muscle health, cardiorespiratory fitness, and their roles in aging and disease prevention.