• Structural disconnectivity in...

Treffer: Structural disconnectivity in postoperative delirium: A perioperative two-center cohort study in older patients.

Title:
Structural disconnectivity in postoperative delirium: A perioperative two-center cohort study in older patients.
Authors:
Fislage, Marinus, Winzeck, Stefan, Woodrow, Rebecca, Lammers-Lietz, Florian, Stamatakis, Emmanuel A, Correia, Marta M, Preller, Jacobus, Feinkohl, Insa, Hendrikse, Jeroen, Pischon, Tobias, Spies, Claudia D, Slooter, Arjen J C, Winterer, Georg, Menon, David K, Zacharias, Norman, BioCog Consortium, KRAUSE, Roland, SCHNEIDER, Reinhard
Source:
Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 20 (4), 2861 - 2872 (2024-04)
Publisher Information:
John Wiley and Sons Inc
Publication Year:
2024
Collection:
University of Luxembourg: ORBilu - Open Repository and Bibliography
Subject Terms:
brain health, dementia delirium interface, diffusion kurtosis imaging, postoperative delirium, structural disconnectivity, white matter abnormalities, Humans, Aged, Cohort Studies, Diffusion Tensor Imaging/methods, Emergence Delirium, White Matter/diagnostic imaging, Dementia, Diffusion Tensor Imaging, White Matter, Epidemiology, Health Policy, Developmental Neuroscience, Neurology (clinical), Geriatrics and Gerontology, Cellular and Molecular Neuroscience, Psychiatry and Mental Health, Human health sciences, Anesthesia & intensive care, Sciences de la santé humaine, Anesthésie & soins intensifs
Document Type:
Fachzeitschrift article in journal/newspaper
Language:
English
ISSN:
1552-5260
1552-5279
Relation:
urn:issn:1552-5260; urn:issn:1552-5279; https://orbilu.uni.lu/handle/10993/64751; info:hdl:10993/64751; https://orbilu.uni.lu/bitstream/10993/64751/1/Structural%20disconnectivity%20in%20postoperative%20delirium_%20A%20perioperative%20two%e2%80%90center%20cohort%20study%20in%20older%20patients.pdf; info:pmid:38451782; wos:001180945100001
DOI:
10.1002/alz.13749
Availability:
https://orbilu.uni.lu/handle/10993/64751
https://orbilu.uni.lu/bitstream/10993/64751/1/Structural%20disconnectivity%20in%20postoperative%20delirium_%20A%20perioperative%20two%e2%80%90center%20cohort%20study%20in%20older%20patients.pdf
https://doi.org/10.1002/alz.13749
Rights:
open access ; http://purl.org/coar/access_right/c_abf2 ; info:eu-repo/semantics/openAccess
Accession Number:
edsbas.5E5ED6F4
Database:
BASE

Weitere Informationen

peer reviewed ; [en] BACKGROUND: Structural disconnectivity was found to precede dementia. Global white matter abnormalities might also be associated with postoperative delirium (POD). METHODS: We recruited older patients (≥65 years) without dementia that were scheduled for major surgery. Diffusion kurtosis imaging metrics were obtained preoperatively, after 3 and 12 months postoperatively. We calculated fractional anisotropy (FA), mean diffusivity (MD), mean kurtosis (MK), and free water (FW). A structured and validated delirium assessment was performed twice daily. RESULTS: Of 325 patients, 53 patients developed POD (16.3%). Preoperative global MD (standardized beta 0.27 [95% confidence interval [CI] 0.21-0.32] p < 0.001) was higher in patients with POD. Preoperative global MK (-0.07 [95% CI -0.11 to (-0.04)] p < 0.001) and FA (0.07 [95% CI -0.10 to (-0.04)] p < 0.001) were lower. When correcting for baseline diffusion, postoperative MD was lower after 3 months (0.05 [95% CI -0.08 to (-0.03)] p < 0.001; n = 183) and higher after 12 months (0.28 [95% CI 0.20-0.35] p < 0.001; n = 45) among patients with POD. DISCUSSION: Preoperative structural disconnectivity was associated with POD. POD might lead to white matter depletion 3 and 12 months after surgery.