Treffer: New Medulloblastoma Study Findings Recently Were Reported by Researchers at Imperial College London (Transmorphic Phage-guided Systemic Delivery of Tnf & Alpha; Gene for the Treatment of Human Pediatric Medulloblastoma).

Thus, we used a recently designed tumor-targeted bacteriophage (phage)-derived particle, named transmorphic phage/AAV, TPA, to deliver a transgene expressing the tumor necrosis factor-alpha (TNFa) for targeted systemic therapy of medulloblastoma. Systemic administration of RGD4C.TPA.TNFa to mice-bearing subcutaneous medulloblastoma xenografts resulted in selective tumor homing of these particles and consequently, targeted tumor expression of TNFa, apoptosis, and destruction of the tumor vasculature.". [Extracted from the article]