Treffer: Imperial College London Reports Findings in Medulloblastoma (Transmorphic phage-guided systemic delivery of TNFa gene for the treatment of human pediatric medulloblastoma).

Systemic administration of RGD4C.TPA.TNFa to mice-bearing subcutaneous medulloblastoma xenografts resulted in selective tumor homing of these particles and consequently, targeted tumor expression of TNFa, apoptosis, and destruction of the tumor vasculature." Thus, we used a recently designed tumor-targeted bacteriophage (phage)-derived particle, named transmorphic phage/AAV, TPA, to deliver a transgene expressing the tumor necrosis factor-alpha (TNFa) for targeted systemic therapy of medulloblastoma. [Extracted from the article]

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