Treffer: Survival rates of CAD/CAM ceramic dental restorations: A meta-analysis.
Title:
Survival rates of CAD/CAM ceramic dental restorations: A meta-analysis.
Authors:
Source:
Medicine [Medicine (Baltimore)] 2026 Jan 23; Vol. 105 (4), pp. e47221.
Publication Type:
Journal Article; Meta-Analysis; Systematic Review
Language:
English
Journal Info:
Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE
Imprint Name(s):
Original Publication: Hagerstown, Md : Lippincott Williams & Wilkins
MeSH Terms:
References:
Suganna M, Kausher H, Tarek Ahmed S, et al. Contemporary evidence of CAD-CAM in dentistry: a systematic review. Cureus. 2022;14:e31687.
Solís Pinargote NW, Yanushevich O, Krikheli N, et al. Materials and methods for all-ceramic dental restorations using computer-aided design (CAD) and computer-aided manufacturing (CAM) technologies-A brief review. Dent J (Basel). 2024;12:47.
Rexhepi I, Santilli M, D’Addazio G, et al. Clinical applications and mechanical properties of CAD-CAM materials in restorative and prosthetic dentistry: a systematic review. J Funct Biomater. 2023;14:431.
Rodrigues SB, Franken P, Celeste RK, Leitune VCB, Collares FM. CAD/CAM or conventional ceramic materials restorations longevity: a systematic review and meta-analysis. J Prosthodont Res. 2019;63:389–95.
Han M-K. Advances and challenges in zirconia-based materials for dental applications. J Korean Ceram Soc. 2024;61:783–99.
Mohammadi H, Beddu S, Petrů M, et al. Advances in silicon nitride ceramic biomaterials for dental applications – A review. J Mater Res Technol. 2024;28:2778–91.
Skorulska A, Piszko P, Rybak Z, Szymonowicz M, Dobrzyński M. Review on polymer, ceramic and composite materials for CAD/CAM indirect restorations in dentistry-application, mechanical characteristics and comparison. Materials (Basel). 2021;14:1592.
Alayad AS, Alqhatani A, Alkatheeri MS, et al. Effects of CAD/CAM ceramics and thicknesses on translucency and color masking of substrates. The Saudi Dental Journal. 2021;33:761–8.
Li RWK, Chow TW, Matinlinna JP. Ceramic dental biomaterials and CAD/CAM technology: state of the art. J Prosthodont Res. 2014;58:208–16.
Spitznagel FA, Boldt J, Gierthmuehlen PC. CAD/CAM ceramic restorative materials for natural teeth. J Dent Res. 2018;97:1082–91.
Gopal S. CAD-CAM and all ceramic restorations, current trends and emerging technologies: a review. Int J Orofac Res. 2017;2:40–4.
Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.
Sterne JAC, Savović J, Page MJ, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898.
Wells GA, Wells G, Shea B, et al. The newcastle-ottawa scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2014.
Guyatt G, Oxman AD, Akl EA, et al. GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. J Clin Epidemiol. 2011;64:383–94.
Yu F, Xiang F, Zhao J, Lin N, Sun Z, Zheng Y. Clinical outcomes of self-glazed zirconia veneers produced by 3D gel deposition: a retrospective study. BMC Oral Health. 2024;24:457.
Schubert O, Goob J, Schweiger J, Güth JF, Edelhoff D, Graf T. Clinical performance of monolithic lithium disilicate hybrid abutment crowns over at least 3.5 years. J Prosthodont. 2024;33:34–40.
Pontevedra P, Lopez-Suarez C, Rodriguez V, Tobar C, Pelaez J, Suarez MJ. Digital workflow for monolithic and veneered zirconia and metal-ceramic posterior fixed partial dentures: a five-year prospective randomized clinical trial. J Prosthodont Res. 2024;68:78–84.
Wittneben JG, Abou-Ayash S, Gashi A, et al. Implant-supported single all-ceramic crowns made from prefabricated (stock) or individualized CAD/CAM zirconia abutments: a 5 year randomized clinical trial. J. Esthet. Restor. Dent. 2024;36:164–73.
Hassan A, Hamdi K, Ali AI, Al-Zordk W, Mahmoud SH. Clinical performance comparison between lithium disilicate and hybrid resin nano-ceramic CAD/CAM onlay restorations: a two-year randomized clinical split-mouth study. Odontology. 2024;112:601–15.
Aziz AM, Suliman S, Sulaiman TA, Abdulmajeed A. Clinical and radiographical evaluation of CAD-CAM crowns with and without deep margin elevation: 10-year results. J Prosthet Dent. 2024;134:1125–32.
Zhang Y, Wei D, Tian J, Zhao Y, Lin Y, Di P. Clinical evaluation and quantitative occlusal change analysis of posterior implant-supported all-ceramic crowns: a 3-year randomized controlled clinical trial. Clin Oral Implants Res. 2023;34:1188–97.
Montaser AG, Hashem SN, Ali MA, Fathy NA, Safwat HA, Eldehna AM. Clinical performance of two CAD/CAM fabricated ceramic restorations with different designs for MIH rehabilitation: a randomized controlled trial. Open Dent J. 2023;17.
Zhang L, Hou XX, Aishan M, Tian MT, He HY. A 3-year clinical evaluation of endodontically treated posterior teeth restored with resin nanoceramic computer-aided design/computer aided manufacture (CAD/CAM)-fabricated partial crowns. Med Sci Monit. 2022;28.
Mijiritsky E, Elad A, Krausz R, Ivanova V, Zlatev S. Clinical performance of full-arch implant-supported fixed restorations made of monolithic zirconia luted to a titanium bar: a retrospective study with a mean follow-up of 16 months. J Dent. 2023;137:104675.
Ying S, Chen S, Wang S, et al. Outcome of teeth restored with CAD/CAM zirconium dioxide post-cores: a retrospective study with a follow-up period of 3-6 years. BMC oral health. 2022;22:236.
Schlichting LH, Resende TH, Reis KR, Raybolt Dos Santos A, Correa IC, Magne P. Ultrathin CAD-CAM glass-ceramic and composite resin occlusal veneers for the treatment of severe dental erosion: an up to 3-year randomized clinical trial. J Prosthet Dent. 2022;128:158.e1–158.e12.
Salem MT, El-Layeh M, El-Farag SAA, Salem AS, Attia A. Clinical assessment of different implant-supported esthetic crown systems fabricated with semi-digital workflow: two-year prospective study. J. Esthet. Restor. Dent. 2022;34:1247–62.
Pontevedra P, Lopez-Suarez C, Rodriguez V, Pelaez J, Suarez MJ. Randomized clinical trial comparing monolithic and veneered zirconia three-unit posterior fixed partial dentures in a complete digital flow: three-year follow-up. Clin Oral Investig. 2022;26:4327–35.
El-Ma’aita A, AA-Ra M, Abu-Awwad M, Hattar S, Devlin H. Endocrowns clinical performance and patient satisfaction: a randomized clinical trial of three monolithic ceramic restorations. J Prosthodont. 2022;31:30–7.
Canatan S, Oz FD, Bolay S. A randomized, controlled clinical evaluation of two resin cement systems in the adhesion of CAD/CAM-fabricated resin nanoceramic restorations: 18-month preliminary results. J. Esthet. Restor. Dent. 2022;34:1005–14.
Bompolaki D, Punj A, Fellows C, Truong C, Ferracane JL. Clinical Performance of CAD/CAM monolithic lithium disilicate implant-supported single crowns using solid or predrilled blocks in a fully digital workflow: a retrospective cohort study with up to 33 months of follow up. J Prosthodont. 2022;31:38–44.
Aziz AM, El-Mowafy O, Tenenbaum HC, Lawrence HP. Clinical performance of CAD-CAM crowns provided by predoctoral students at the University of Toronto. J Prosthet Dent. 2022;127:729–36.
Wittneben JG, Gavric J, Sailer I, Buser D, Wismeijer D. Clinical and esthetic outcomes of two different prosthetic workflows for implant-supported all-ceramic single crowns-3 year results of a randomized multicenter clinical trail. Clin Oral Implants Res. 2020;31:495–505.
Seidel A, Belli R, Breidebach N, Wichmann M, Matta RE. The occlusal wear of ceramic fixed dental prostheses: 3-Year results in a randomized controlled clinical trial with split-mouth design. J Dent. 2020;103:103500.
Mühlemann S, Lakha T, Jung RE, Hämmerle CHF, Benic GI. Prosthetic outcomes and clinical performance of CAD-CAM monolithic zirconia versus porcelain-fused-to-metal implant crowns in the molar region: 1-year results of a RCT. Clin Oral Implants Res. 2020;31:856–64.
De Angelis P, Passarelli PC, Gasparini G, Boniello R, D’Amato G, De Angelis S. Monolithic CAD-CAM lithium disilicate versus monolithic CAD-CAM zirconia for single implant-supported posterior crowns using a digital workflow: a 3-year cross-sectional retrospective study. J Prosthet Dent. 2020;123:252–6.
Spitznagel FA, Scholz KJ, Strub JR, Vach K, Gierthmuehlen PC. Polymer-infiltrated ceramic CAD/CAM inlays and partial coverage restorations: 3-year results of a prospective clinical study over 5 years. Clin Oral Investig. 2018;22:1973–83.
Wittneben JG, Gavric J, Belser UC, et al. Esthetic and clinical performance of implant-supported all-ceramic crowns made with prefabricated or CAD/CAM zirconia abutments: a randomized, multicenter clinical trial. J Dent Res. 2017;96:163–70.
Hey J, Beuer F, Bensel T, Boeckler AF. Metal-ceramic-fixed dental prosthesis with CAD/CAM-fabricated substructures: 6-year clinical results. Clin Oral Investig. 2013;17:1447–51.
Yeslam HE, Freifrau von Maltzahn N, Nassar HM. Revolutionizing CAD/CAM-based restorative dental processes and materials with artificial intelligence: a concise narrative review. PeerJ. 2024;12:e17793.
Regassa Hunde B, Debebe Woldeyohannes A. Future prospects of computer-aided design (CAD) – A review from the perspective of artificial intelligence (AI), extended reality, and 3D printing. Results in Engineering. 2022;14:100478.
Habibzadeh S, Khamisi F, Mosaddad SA, Fernandes GVO, Heboyan A. Full-ceramic resin-bonded fixed dental prostheses: a systematic review. J Appl Biomater Funct Mater. 2024;22:22808000241250118.
Aswal GS, Rawat R, Dwivedi D, Prabhakar N, Kumar V. Clinical outcomes of CAD/CAM (Lithium disilicate and Zirconia) based and conventional full crowns and fixed partial dentures: a systematic review and meta-analysis. Cureus. 2023;15:e37888.
Warreth A, Elkareimi Y. All-ceramic restorations: a review of the literature. Saudi Dent J. 2020;32:365–72.
Liu F, Zhan Y, Liu X. Clinical solutions for natural abutments with preexisting defected crown margin in the aesthetic area. Hua Xi Kou Qiang Yi Xue Za Zhi. 2023;41:641–6.
Naik VB, Jain AK, Rao RD, Naik BD. Comparative evaluation of clinical performance of ceramic and resin inlays, onlays, and overlays: a systematic review and meta analysis. J Conserv Dent. 2022;25:347–55.
Bajoria S, Shetty SR, Bandela V, et al. Evaluation and comparison of the effect of three dental luting cements on mineralized bone derived from dental pulp stem cells: an in vitro study. Medicina. 2024;60:1622.
Sartoretto SC, Shibli JA, Javid K, et al. Comparing the long-term success rates of tooth preservation and dental implants: a critical review. J Funct Biomater. 2023;14:142.
Kadkhodazadeh M, Amid R, Moscowchi A, Lakmazaheri E. Short-term and long-term success and survival rates of implants supporting single-unit and multiunit fixed prostheses: a systematic review and meta-analysis. J Prosthet Dent. 2023;132:1226–36.
Poggio C, Arciola CR, Rosti F, Scribante A, Saino E, Visai L. Adhesion of streptococcus mutans to different restorative materials. Int J Artif Organs. 2009;32:671–7.
Barreto LAL, Grangeiro MTV, Prado PHCO, et al. Effect of finishing protocols on the surface roughness and fatigue strength of a high-translucent zirconia. Int J Dent. 2023.
Cacciafesta V, Sfondrini MF, Lena A, Scribante A, Vallittu PK, Lassila LV. Flexural strengths of fiber-reinforced composites polymerized with conventional light-curing and additional postcuring. Am J Orthod Dentofacial Orthop. 2007;132:524–7.
Solís Pinargote NW, Yanushevich O, Krikheli N, et al. Materials and methods for all-ceramic dental restorations using computer-aided design (CAD) and computer-aided manufacturing (CAM) technologies-A brief review. Dent J (Basel). 2024;12:47.
Rexhepi I, Santilli M, D’Addazio G, et al. Clinical applications and mechanical properties of CAD-CAM materials in restorative and prosthetic dentistry: a systematic review. J Funct Biomater. 2023;14:431.
Rodrigues SB, Franken P, Celeste RK, Leitune VCB, Collares FM. CAD/CAM or conventional ceramic materials restorations longevity: a systematic review and meta-analysis. J Prosthodont Res. 2019;63:389–95.
Han M-K. Advances and challenges in zirconia-based materials for dental applications. J Korean Ceram Soc. 2024;61:783–99.
Mohammadi H, Beddu S, Petrů M, et al. Advances in silicon nitride ceramic biomaterials for dental applications – A review. J Mater Res Technol. 2024;28:2778–91.
Skorulska A, Piszko P, Rybak Z, Szymonowicz M, Dobrzyński M. Review on polymer, ceramic and composite materials for CAD/CAM indirect restorations in dentistry-application, mechanical characteristics and comparison. Materials (Basel). 2021;14:1592.
Alayad AS, Alqhatani A, Alkatheeri MS, et al. Effects of CAD/CAM ceramics and thicknesses on translucency and color masking of substrates. The Saudi Dental Journal. 2021;33:761–8.
Li RWK, Chow TW, Matinlinna JP. Ceramic dental biomaterials and CAD/CAM technology: state of the art. J Prosthodont Res. 2014;58:208–16.
Spitznagel FA, Boldt J, Gierthmuehlen PC. CAD/CAM ceramic restorative materials for natural teeth. J Dent Res. 2018;97:1082–91.
Gopal S. CAD-CAM and all ceramic restorations, current trends and emerging technologies: a review. Int J Orofac Res. 2017;2:40–4.
Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.
Sterne JAC, Savović J, Page MJ, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898.
Wells GA, Wells G, Shea B, et al. The newcastle-ottawa scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2014.
Guyatt G, Oxman AD, Akl EA, et al. GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. J Clin Epidemiol. 2011;64:383–94.
Yu F, Xiang F, Zhao J, Lin N, Sun Z, Zheng Y. Clinical outcomes of self-glazed zirconia veneers produced by 3D gel deposition: a retrospective study. BMC Oral Health. 2024;24:457.
Schubert O, Goob J, Schweiger J, Güth JF, Edelhoff D, Graf T. Clinical performance of monolithic lithium disilicate hybrid abutment crowns over at least 3.5 years. J Prosthodont. 2024;33:34–40.
Pontevedra P, Lopez-Suarez C, Rodriguez V, Tobar C, Pelaez J, Suarez MJ. Digital workflow for monolithic and veneered zirconia and metal-ceramic posterior fixed partial dentures: a five-year prospective randomized clinical trial. J Prosthodont Res. 2024;68:78–84.
Wittneben JG, Abou-Ayash S, Gashi A, et al. Implant-supported single all-ceramic crowns made from prefabricated (stock) or individualized CAD/CAM zirconia abutments: a 5 year randomized clinical trial. J. Esthet. Restor. Dent. 2024;36:164–73.
Hassan A, Hamdi K, Ali AI, Al-Zordk W, Mahmoud SH. Clinical performance comparison between lithium disilicate and hybrid resin nano-ceramic CAD/CAM onlay restorations: a two-year randomized clinical split-mouth study. Odontology. 2024;112:601–15.
Aziz AM, Suliman S, Sulaiman TA, Abdulmajeed A. Clinical and radiographical evaluation of CAD-CAM crowns with and without deep margin elevation: 10-year results. J Prosthet Dent. 2024;134:1125–32.
Zhang Y, Wei D, Tian J, Zhao Y, Lin Y, Di P. Clinical evaluation and quantitative occlusal change analysis of posterior implant-supported all-ceramic crowns: a 3-year randomized controlled clinical trial. Clin Oral Implants Res. 2023;34:1188–97.
Montaser AG, Hashem SN, Ali MA, Fathy NA, Safwat HA, Eldehna AM. Clinical performance of two CAD/CAM fabricated ceramic restorations with different designs for MIH rehabilitation: a randomized controlled trial. Open Dent J. 2023;17.
Zhang L, Hou XX, Aishan M, Tian MT, He HY. A 3-year clinical evaluation of endodontically treated posterior teeth restored with resin nanoceramic computer-aided design/computer aided manufacture (CAD/CAM)-fabricated partial crowns. Med Sci Monit. 2022;28.
Mijiritsky E, Elad A, Krausz R, Ivanova V, Zlatev S. Clinical performance of full-arch implant-supported fixed restorations made of monolithic zirconia luted to a titanium bar: a retrospective study with a mean follow-up of 16 months. J Dent. 2023;137:104675.
Ying S, Chen S, Wang S, et al. Outcome of teeth restored with CAD/CAM zirconium dioxide post-cores: a retrospective study with a follow-up period of 3-6 years. BMC oral health. 2022;22:236.
Schlichting LH, Resende TH, Reis KR, Raybolt Dos Santos A, Correa IC, Magne P. Ultrathin CAD-CAM glass-ceramic and composite resin occlusal veneers for the treatment of severe dental erosion: an up to 3-year randomized clinical trial. J Prosthet Dent. 2022;128:158.e1–158.e12.
Salem MT, El-Layeh M, El-Farag SAA, Salem AS, Attia A. Clinical assessment of different implant-supported esthetic crown systems fabricated with semi-digital workflow: two-year prospective study. J. Esthet. Restor. Dent. 2022;34:1247–62.
Pontevedra P, Lopez-Suarez C, Rodriguez V, Pelaez J, Suarez MJ. Randomized clinical trial comparing monolithic and veneered zirconia three-unit posterior fixed partial dentures in a complete digital flow: three-year follow-up. Clin Oral Investig. 2022;26:4327–35.
El-Ma’aita A, AA-Ra M, Abu-Awwad M, Hattar S, Devlin H. Endocrowns clinical performance and patient satisfaction: a randomized clinical trial of three monolithic ceramic restorations. J Prosthodont. 2022;31:30–7.
Canatan S, Oz FD, Bolay S. A randomized, controlled clinical evaluation of two resin cement systems in the adhesion of CAD/CAM-fabricated resin nanoceramic restorations: 18-month preliminary results. J. Esthet. Restor. Dent. 2022;34:1005–14.
Bompolaki D, Punj A, Fellows C, Truong C, Ferracane JL. Clinical Performance of CAD/CAM monolithic lithium disilicate implant-supported single crowns using solid or predrilled blocks in a fully digital workflow: a retrospective cohort study with up to 33 months of follow up. J Prosthodont. 2022;31:38–44.
Aziz AM, El-Mowafy O, Tenenbaum HC, Lawrence HP. Clinical performance of CAD-CAM crowns provided by predoctoral students at the University of Toronto. J Prosthet Dent. 2022;127:729–36.
Wittneben JG, Gavric J, Sailer I, Buser D, Wismeijer D. Clinical and esthetic outcomes of two different prosthetic workflows for implant-supported all-ceramic single crowns-3 year results of a randomized multicenter clinical trail. Clin Oral Implants Res. 2020;31:495–505.
Seidel A, Belli R, Breidebach N, Wichmann M, Matta RE. The occlusal wear of ceramic fixed dental prostheses: 3-Year results in a randomized controlled clinical trial with split-mouth design. J Dent. 2020;103:103500.
Mühlemann S, Lakha T, Jung RE, Hämmerle CHF, Benic GI. Prosthetic outcomes and clinical performance of CAD-CAM monolithic zirconia versus porcelain-fused-to-metal implant crowns in the molar region: 1-year results of a RCT. Clin Oral Implants Res. 2020;31:856–64.
De Angelis P, Passarelli PC, Gasparini G, Boniello R, D’Amato G, De Angelis S. Monolithic CAD-CAM lithium disilicate versus monolithic CAD-CAM zirconia for single implant-supported posterior crowns using a digital workflow: a 3-year cross-sectional retrospective study. J Prosthet Dent. 2020;123:252–6.
Spitznagel FA, Scholz KJ, Strub JR, Vach K, Gierthmuehlen PC. Polymer-infiltrated ceramic CAD/CAM inlays and partial coverage restorations: 3-year results of a prospective clinical study over 5 years. Clin Oral Investig. 2018;22:1973–83.
Wittneben JG, Gavric J, Belser UC, et al. Esthetic and clinical performance of implant-supported all-ceramic crowns made with prefabricated or CAD/CAM zirconia abutments: a randomized, multicenter clinical trial. J Dent Res. 2017;96:163–70.
Hey J, Beuer F, Bensel T, Boeckler AF. Metal-ceramic-fixed dental prosthesis with CAD/CAM-fabricated substructures: 6-year clinical results. Clin Oral Investig. 2013;17:1447–51.
Yeslam HE, Freifrau von Maltzahn N, Nassar HM. Revolutionizing CAD/CAM-based restorative dental processes and materials with artificial intelligence: a concise narrative review. PeerJ. 2024;12:e17793.
Regassa Hunde B, Debebe Woldeyohannes A. Future prospects of computer-aided design (CAD) – A review from the perspective of artificial intelligence (AI), extended reality, and 3D printing. Results in Engineering. 2022;14:100478.
Habibzadeh S, Khamisi F, Mosaddad SA, Fernandes GVO, Heboyan A. Full-ceramic resin-bonded fixed dental prostheses: a systematic review. J Appl Biomater Funct Mater. 2024;22:22808000241250118.
Aswal GS, Rawat R, Dwivedi D, Prabhakar N, Kumar V. Clinical outcomes of CAD/CAM (Lithium disilicate and Zirconia) based and conventional full crowns and fixed partial dentures: a systematic review and meta-analysis. Cureus. 2023;15:e37888.
Warreth A, Elkareimi Y. All-ceramic restorations: a review of the literature. Saudi Dent J. 2020;32:365–72.
Liu F, Zhan Y, Liu X. Clinical solutions for natural abutments with preexisting defected crown margin in the aesthetic area. Hua Xi Kou Qiang Yi Xue Za Zhi. 2023;41:641–6.
Naik VB, Jain AK, Rao RD, Naik BD. Comparative evaluation of clinical performance of ceramic and resin inlays, onlays, and overlays: a systematic review and meta analysis. J Conserv Dent. 2022;25:347–55.
Bajoria S, Shetty SR, Bandela V, et al. Evaluation and comparison of the effect of three dental luting cements on mineralized bone derived from dental pulp stem cells: an in vitro study. Medicina. 2024;60:1622.
Sartoretto SC, Shibli JA, Javid K, et al. Comparing the long-term success rates of tooth preservation and dental implants: a critical review. J Funct Biomater. 2023;14:142.
Kadkhodazadeh M, Amid R, Moscowchi A, Lakmazaheri E. Short-term and long-term success and survival rates of implants supporting single-unit and multiunit fixed prostheses: a systematic review and meta-analysis. J Prosthet Dent. 2023;132:1226–36.
Poggio C, Arciola CR, Rosti F, Scribante A, Saino E, Visai L. Adhesion of streptococcus mutans to different restorative materials. Int J Artif Organs. 2009;32:671–7.
Barreto LAL, Grangeiro MTV, Prado PHCO, et al. Effect of finishing protocols on the surface roughness and fatigue strength of a high-translucent zirconia. Int J Dent. 2023.
Cacciafesta V, Sfondrini MF, Lena A, Scribante A, Vallittu PK, Lassila LV. Flexural strengths of fiber-reinforced composites polymerized with conventional light-curing and additional postcuring. Am J Orthod Dentofacial Orthop. 2007;132:524–7.
Contributed Indexing:
Keywords: CAD/CAM; ceramic dental restorations; dentistry; meta-analysis; survival rates
Entry Date(s):
Date Created: 20260124 Date Completed: 20260124 Latest Revision: 20260127
Update Code:
20260127
DOI:
10.1097/MD.0000000000047221
PMID:
41578458
Database:
MEDLINE
Weitere Informationen
Background: The aim of this systematic review was to evaluate the survival rates of computer-aided design/computer-aided manufacturing ceramic dental restorations.
Methods: The study followed PRISMA guidelines and the study protocol was pre-registered on the PROSPERO platform (registration number: CRD42024599053). Randomized controlled trials (RCTs) and cohort studies with a minimum follow-up period of 1-year were included. The search period was set from 2000 to May 2024. A Comprehensive Literature Search was Performed in MEDLINE (PubMed), Scopus, and the Cochrane Central Register of Controlled Trials. Additionally, references list of relevant reviews and full-text articles were hand-searched to identify potentially eligible studies.
Results: A total of 714 articles were identified in the initial search. After screening titles and abstracts, 31 studies were selected for full-text review. Following the application of inclusion and exclusion criteria, 25 studies-comprising 13 RCTs and 12 cohort studies-were incorporated into the systematic review. Quality assessment and risk of bias were conducted using 2 established scales. Regarding survival rates, the overall heterogeneity (I2) among the RCTs was calculated at 23% (P = .17). The pooled survival rate across these trials was determined to be 96% (95% confidence interval: 94-98%), with a mean follow-up period extending from 12 to 64 months.
Conclusion: Ceramic restorations with computer-aided design/computer-aided manufacturing have shown high survival rates in either randomized controlled studies or cohort studies. Meta-analysis results showed high heterogeneity in cohort studies, so randomized controlled studies with a larger number of participants are still needed to prove their clinical effectiveness.
(Copyright © 2026 the Author(s). Published by Wolters Kluwer Health, Inc.)
The authors have no funding and conflicts of interest to disclose.