• Assessing Cardiac 2D Flow MRI...

Treffer: Assessing Cardiac 2D Flow MRI Reliability across Various Physiologic, Technical, and Observer Confounders in Healthy Traveling Volunteers.

Title:
Assessing Cardiac 2D Flow MRI Reliability across Various Physiologic, Technical, and Observer Confounders in Healthy Traveling Volunteers.
Authors:
Trauzeddel RF; ECRC Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, a joint cooperation between the Charité-Universitätsmedizin Berlin and the Max-Delbrück-Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.; Department of Anesthesiology and Intensive Care Medicine, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charité Campus Benjamin Franklin, Berlin, Germany., Grandy TH; Department of Cardiology and Nephrology, HELIOS Klinikum Berlin Buch, Berlin, Germany., Daud E; ECRC Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, a joint cooperation between the Charité-Universitätsmedizin Berlin and the Max-Delbrück-Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.; The Cardiology Department, Galilee Medical Center, Azrieli Faculty of Medicine Bar-Ilan University, Nahariya-Safed, Israel., Müller M; ECRC Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, a joint cooperation between the Charité-Universitätsmedizin Berlin and the Max-Delbrück-Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Berlin, Berlin, Germany., Gröschel J; ECRC Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, a joint cooperation between the Charité-Universitätsmedizin Berlin and the Max-Delbrück-Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Berlin, Berlin, Germany., Viezzer D; ECRC Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, a joint cooperation between the Charité-Universitätsmedizin Berlin and the Max-Delbrück-Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Berlin, Berlin, Germany., Hadler T; ECRC Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, a joint cooperation between the Charité-Universitätsmedizin Berlin and the Max-Delbrück-Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Berlin, Berlin, Germany., Blaszczyk E; ECRC Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, a joint cooperation between the Charité-Universitätsmedizin Berlin and the Max-Delbrück-Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Berlin, Berlin, Germany., Jin N; Cardiovascular MR R&D, Siemens Healthcare, Erlangen, Germany., Giese D; Magnetic Resonance, Siemens Healthcare, Erlangen, Germany.; Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany., Schulz-Menger J; ECRC Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, a joint cooperation between the Charité-Universitätsmedizin Berlin and the Max-Delbrück-Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.; Department of Cardiology and Nephrology, HELIOS Klinikum Berlin Buch, Berlin, Germany.
Source:
Radiology. Cardiothoracic imaging [Radiol Cardiothorac Imaging] 2026 Feb; Vol. 8 (1), pp. e240247.
Publication Type:
Journal Article; Observational Study
Language:
English
Journal Info:
Publisher: Radiological Society of North America, Inc Country of Publication: United States NLM ID: 101748663 Publication Model: Print Cited Medium: Internet ISSN: 2638-6135 (Electronic) Linking ISSN: 26386135 NLM ISO Abbreviation: Radiol Cardiothorac Imaging Subsets: MEDLINE
Imprint Name(s):
Original Publication: Oak Brook, IL : Radiological Society of North America, Inc., [2019]-
MeSH Terms:
Magnetic Resonance Imaging*/methods , Heart*/diagnostic imaging, Humans ; Male ; Adult ; Reproducibility of Results ; Female ; Prospective Studies ; Healthy Volunteers ; Observer Variation ; Blood Flow Velocity/physiology
Contributed Indexing:
Keywords: 2D Flow Cardiac MRI; 4D Flow Cardiac MRI; Cardiac MRI; Phase-Contrast MRI; Postprocessing; Reliability; Traveling Volunteers; Validation
Entry Date(s):
Date Created: 20260108 Date Completed: 20260108 Latest Revision: 20260115
Update Code:
20260116
DOI:
10.1148/ryct.240247
PMID:
41504646
Database:
MEDLINE

Weitere Informationen

Purpose To evaluate the repeatability and reproducibility of phase-contrast two-dimensional blood flow cardiac MRI (2D flow) measurements in the presence of physiologic, technical, and observer confounders. Materials and Methods In this prospective observational study from January to June 2022, 20 healthy volunteers underwent 2D flow cardiac MRI at four sites (one 1.5-T and three 3-T scanners). Each participant received two consecutive segmented gradient-echo acquisitions and one real-time sequence with a scan-rescan examination at one site. Intraclass correlation coefficients (ICC) assessed sequence repeatability, scan-rescan reproducibility, sequence-type comparison, field-strength and scanner-configuration effects, and interobserver agreement. Correlations between forward flow volume (FF), peak velocity (PV), heart rate, and blood pressure were calculated using Pearson and Spearman coefficients. Segmented 2D flow cardiac MRI was compared with four-dimensional flow cardiac MRI at the sinotubular junction and aortic valve. Results Nineteen participants (mean age, 26 years ± 6 [SD]; 11 male participants) were analyzed. FF and PV demonstrated excellent sequence repeatability (ICC, 0.986 and 0.969, respectively) and scan-rescan reproducibility (ICC, 0.976 and 0.903, respectively). Different sequence types and field strengths showed excellent agreement for FF (ICC for sequence type, 0.925; ICC for field strength, 0.918), as did different scanner configurations and interobserver analyses with measurements within equivalence limits, except for PV across sequence types, field strengths, and between sites 2 and 3. Heart rate and FF correlated mildly ( r , -0.40) but not systolic or diastolic blood pressure with FF and PV and heart rate with PV ( r , -0.02). 2D and four-dimensional flow cardiac MRI correlated and had good to excellent agreement with FF at the sinotubular junction and aortic valve ( r , 0.86; ICC, 0.930 and r , 0.89; ICC, 0.939, respectively) and moderate for PV ( r , 0.77; ICC, 0.862 and r , 0.66; ICC, 0.767, respectively). Conclusion 2D flow cardiac MRI measurements showed excellent repeatability for FF and moderate agreement for PV across sequences, field strengths, and observers. Physiologic and technical confounders had minimal impact on measurement precision. Keywords: Cardiac MRI, 2D Flow Cardiac MRI, 4D Flow Cardiac MRI, Phase-Contrast MRI, Traveling Volunteers, Validation, Reliability, Postprocessing Supplemental material is available for this article. ISRCTN Registry no. 14627679 © RSNA, 2026.