• From Hype to Hope: Deconstruct...

Treffer: From Hype to Hope: Deconstructing the translational barriers and Charting a new roadmap for Ultrasound-Responsive nanobubbles.

Title:
From Hype to Hope: Deconstructing the translational barriers and Charting a new roadmap for Ultrasound-Responsive nanobubbles.
Authors:
Chen T; Wujin Hospital Affiliated With Jiangsu University, Changzhou, Jiangsu, China., Chen M; School of Medicine Southeast University, Nanjing, Jiangsu, China; Department of Orthopaedics, Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu, China., Song R; Wujin Hospital Affiliated With Jiangsu University, Changzhou, Jiangsu, China., Chen J; School of Medicine Jiangsu University, Zhenjiang, Jiangsu, China., Wang Y; Nanjing Medical University, Nanjing, Jiangsu, China., Yu X; Wujin Hospital Affiliated With Jiangsu University, Changzhou, Jiangsu, China; Center of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao Road, Nanjing 210009, China. Electronic address: yuxiaolong@wjrmyy.cn.
Source:
International journal of pharmaceutics [Int J Pharm] 2026 Jan 20; Vol. 689, pp. 126525. Date of Electronic Publication: 2025 Dec 21.
Publication Type:
Journal Article; Review
Language:
English
Journal Info:
Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE
Imprint Name(s):
Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
MeSH Terms:
Translational Research, Biomedical*/methods , Drug Delivery Systems*/methods , Microbubbles*, Humans ; Animals ; Theranostic Nanomedicine/methods ; Ultrasonic Waves ; Precision Medicine/methods
Contributed Indexing:
Keywords: Biomedical translation roadmap; Drug delivery systems; Nanomaterial standardization; Translational medicine; Ultrasound-responsive nanobubbles
Entry Date(s):
Date Created: 20251223 Date Completed: 20260108 Latest Revision: 20260108
Update Code:
20260109
DOI:
10.1016/j.ijpharm.2025.126525
PMID:
41435931
Database:
MEDLINE

Weitere Informationen

Ultrasound-Responsive Nanobubbles (URNBs), envisioned as an integrated theranostic platform capable of precise drug delivery and high-resolution imaging, possessing the transformative potential to reshape the landscape of precision medicine. However, an undeniable reality remains: despite an exponential increase in academic outputs, their clinical translation has stagnated almost entirely. We argue that this gap stems not from technological limits, but from a systemic flaw in the prevailing R&D paradigm. This flaw manifests as: (1) A disjunction between laboratory research and manufacturing; (2) A "predictive crisis" in translating physicochemical properties to biological effects; (3) A lack of co-design between technological innovation and clinical needs. To address these challenges systematically, this review extracts "translational wisdom" from the success stories of approved microbubble agents, conducts an comprehensive analysis of the core barriers impeding URNBs development, and, on this basis, for the first time proposes a "Design for Translation" (DFT) framework aimed at reshaping the research and development (R&D) trajectory. The framework articulates a holistic solution structured around four mutually reinforcing pillars: (1) process optimization driven by clearly defined clinical endpoints; (2) strategic progression from a minimum viable product to a derivable technology platform; (3) integration of bubble, drug, and device into a cohesive technological ecosystem; (4) cultivation of multidisciplinary talent within a supportive innovation environment. At its core, this framework reorients the innovation process by taking the endpoint (i.e., clinical value) as the starting point and replacing the prevailing fragmented, bottom-up technological exploration with an integrated, top-down design strategy. In doing so, it offers a strategic roadmap for navigating the "translational maze" of URNBs-transforming them from an academic "Hype" into a tangible clinical "Hope".
(Copyright © 2025 Elsevier B.V. All rights reserved.)

Declaration of competing interest The authors declare that they have no known competing fnancial interests or personal relationships that could have appeared to infuence the work reported in this paper.