Treffer: Different Orientations Moderate Static Magnetic Fields Prevent Bone Loss and Improve the Mechanical Properties in Ovariectomized Mice.
Title:
Different Orientations Moderate Static Magnetic Fields Prevent Bone Loss and Improve the Mechanical Properties in Ovariectomized Mice.
Authors:
Wang S; Department of Spine Surgery, People's Hospital of Longhua, Affiliated Hospital of Southern Medical University, Shenzhen, China.; School of Chinese Medicine, Law Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases (TMBJ), Hong Kong Baptist University, Hong Kong, China., Chen J; Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, China.; Key Laboratory for Space Biosciences and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi, China.; School of Life Sciences, Northwestern Polytechnical University, Xi'an, China., Wang H; Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, China.; Key Laboratory for Space Biosciences and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi, China.; School of Life Sciences, Northwestern Polytechnical University, Xi'an, China., Cai C; Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, China.; Key Laboratory for Space Biosciences and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi, China.; School of Life Sciences, Northwestern Polytechnical University, Xi'an, China., Ren W; Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, China.; Key Laboratory for Space Biosciences and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi, China.; School of Life Sciences, Northwestern Polytechnical University, Xi'an, China., Liu J; Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, China.; Key Laboratory for Space Biosciences and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi, China.; School of Life Sciences, Northwestern Polytechnical University, Xi'an, China., Hu Y; Department of Spine Surgery, People's Hospital of Longhua, Affiliated Hospital of Southern Medical University, Shenzhen, China., Gong M; Department of Spine Surgery, People's Hospital of Longhua, Affiliated Hospital of Southern Medical University, Shenzhen, China., Liu Z; Department of Spine Surgery, People's Hospital of Longhua, Affiliated Hospital of Southern Medical University, Shenzhen, China., Guo Z; Department of Spine Surgery, People's Hospital of Longhua, Affiliated Hospital of Southern Medical University, Shenzhen, China., Shang P; Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, China.; Key Laboratory for Space Biosciences and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi, China., Zhang H; Department of Spine Surgery, People's Hospital of Longhua, Affiliated Hospital of Southern Medical University, Shenzhen, China.
Source:
Bioelectromagnetics [Bioelectromagnetics] 2025 Dec; Vol. 46 (8), pp. e70037.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8008281 Publication Model: Print Cited Medium: Internet ISSN: 1521-186X (Electronic) Linking ISSN: 01978462 NLM ISO Abbreviation: Bioelectromagnetics Subsets: MEDLINE
Imprint Name(s):
Publication: New York, NY : Wiley-Liss
Original Publication: New York, Liss.
Original Publication: New York, Liss.
MeSH Terms:
References:
Andreopoulou, P., and R. S. Bockman. 2015. “Management of Postmenopausal Osteoporosis.” Annual Review of Medicine 66: 329–342.
Caliogna, L., V. Bina, A. M. Brancato, et al. 2022. “The Role of PEMFs on Bone Healing: An In Vitro Study.” International Journal of Molecular Sciences 23: 14298.
Caliogna, L., M. Medetti, V. Bina, et al. 2021. “Pulsed Electromagnetic Fields in Bone Healing: Molecular Pathways and Clinical Applications.” International Journal of Molecular Sciences 22: 7403.
Clézardin, P., R. Coleman, M. Puppo, et al. 2021. “Bone Metastasis: Mechanisms, Therapies, and Biomarkers.” Physiological Reviews 101: 797–855.
Compston, J. E., M. R. McClung, and W. D. Leslie. 2019. “Osteoporosis.” Lancet 393: 364–376.
Degen, I. L., and V. I. Stetsula. 1971. “[Consolidation of Bone Fragments in a Constant Magnetic Field].” Ortopediia Travmatologiia i Protezirovanie 32: 45–48.
Durmus, N. G., H. C. Tekin, S. Guven, et al. 2015. “Magnetic Levitation of Single Cells.” Proceedings of the National Academy of Sciences 112: E3661–E3668.
Fischer, V., and M. Haffner‐Luntzer. 2022. “Interaction Between Bone and Immune Cells: Implications for Postmenopausal Osteoporosis.” Seminars in Cell & Developmental Biology 123: 14–21.
Hosseini, S., H. Parsaei, M. Moosavifar, N. Tavakoli, R. Ahadi, and K. Roshanbinfar. 2024. “Static Magnetic Field Enhances the Bone Remodelling Capacity of Human Demineralized Bone Matrix in a Rat Animal Model of Cranial Bone Defects.” Journal of Materials Chemistry B 12: 3774–3785.
Houpt, T. A., and C. E. Houpt. 2010. “Circular Swimming in Mice After Exposure to a High Magnetic Field.” Physiology & Behavior 100: 284–290.
Houpt, T. A., D. W. Pittman, J. M. Barranco, E. H. Brooks, and J. C. Smith. 2003. “Behavioral Effects of High‐Strength Static Magnetic Fields on Rats.” Journal of Neuroscience 23: 1498–1505.
Kim, E. C., R. Leesungbok, S. W. Lee, et al. 2015. “Effects of Moderate Intensity Static Magnetic Fields on Human Bone Marrow‐Derived Mesenchymal Stem Cells.” Bioelectromagnetics 36: 267–276.
Kim, E. C., J. Park, G. Noh, et al. 2018. “Effects of Moderate Intensity Static Magnetic Fields on Osteoclastic Differentiation in Mouse Bone Marrow Cells.” Bioelectromagnetics 39: 394–404.
Kotani, H., H. Kawaguchi, T. Shimoaka, et al. 2002. “Strong Static Magnetic Field Stimulates Bone Formation to a Definite Orientation In Vitro and In Vivo.” Journal of Bone and Mineral Research 17: 1814–1821.
De Luka, S. R., A. Ž. Ilić, S. Janković, et al. 2016. “Subchronic Exposure to Static Magnetic Field Differently Affects Zinc and Copper Content in Murine Organs.” International Journal of Radiation Biology 92: 140–147.
Milovanovich, I. D., S. Ćirković, S. R. De Luka, et al. 2016. “Homogeneous Static Magnetic Field of Different Orientation Induces Biological Changes in Subacutely Exposed Mice.” Environmental Science and Pollution Research 23: 1584–1597.
Minoia, A., L. Dalle Carbonare, J. C. Schwamborn, S. Bolognin, and M. T. Valenti. 2022. “Bone Tissue and the Nervous System: What Do They Have in Common?” Cells 12: 51.
Morgan, E. F., G. U. Unnikrisnan, and A. I. Hussein. 2018. “Bone Mechanical Properties in Healthy and Diseased States.” Annual Review of Biomedical Engineering 20: 119–143.
Oftadeh, R., M. Perez‐Viloria, J. C. Villa‐Camacho, A. Vaziri, and A. Nazarian. 2015. “Biomechanics and Mechanobiology of Trabecular Bone: A Review.” Journal of Biomechanical Engineering 137: 0108021–01080215.
Roberts, D. C., V. Marcelli, J. S. Gillen, J. P. Carey, C. C. Della Santina, and D. S. Zee. 2011. “MRI Magnetic Field Stimulates Rotational Sensors of the Brain.” Current Biology 21: 1635–1640.
Song, C., H. Chen, B. Yu, et al. 2023. “Magnetic Fields Affect Alcoholic Liver Disease by Liver Cell Oxidative Stress and Proliferation Regulation.” Research A Journal of Science and Its Applications 6: 0097.
Song, S., Y. Guo, Y. Yang, and D. Fu. 2022. “Advances in Pathogenesis and Therapeutic Strategies for Osteoporosis.” Pharmacology & Therapeutics 237: 108168.
Tasic, T., M. Lozić, S. Glumac, et al. 2021. “Static Magnetic Field on Behavior, Hematological Parameters and Organ Damage in Spontaneously Hypertensive Rats.” Ecotoxicology and Environmental Safety 207: 111085.
Tian, X., D. Wang, M. Zha, et al. 2018. “Magnetic Field Direction Differentially Impacts the Growth of Different Cell Types.” Electromagnetic Biology and Medicine 37: 114–125.
Walker, M. D., and E. Shane. 2023. “Postmenopausal Osteoporosis.” New England Journal of Medicine 389: 1979–1991.
Wang, S., Y. Liu, C. Lou, et al. 2023. “Moderate Static Magnetic Field Promotes Fracture Healing and Regulates Iron Metabolism in Mice.” Biomedical Engineering Online 22: 107.
Wiltschko, W., and R. Wiltschko. 2005. “Magnetic Orientation and Magnetoreception in Birds and Other Animals.” Journal of Comparative Physiology A 191: 675–693.
Wu, A. M., C. Bisignano, S. L. James, et al. 2021. “Global, Regional, and National Burden of Bone Fractures in 204 Countries and Territories, 1990–2019: A Systematic Analysis From the Global Burden of Disease Study 2019.” Lancet Healthy Longevity 2: e580–e592.
Xie, W., C. Song, R. Guo, and X. Zhang. 2024. “Static Magnetic Fields in Regenerative Medicine.” APL Bioengineering 8: 011503.
Yang, J., S. Zhou, M. Wei, Y. Fang, and P. Shang. 2021. “Moderate Static Magnetic Fields Prevent Bone Architectural Deterioration and Strength Reduction in Ovariectomized Mice.” IEEE Transactions on Magnetics 57: 1–9.
Yu, B., J. Liu, J. Cheng, et al. 2021. “A Static Magnetic Field Improves Iron Metabolism and Prevents High‐Fat‐Diet/Streptozocin‐Induced Diabetes.” Innovation 2: 100077.
Zhang, B., X. Yuan, H. Lv, J. Che, S. Wang, and P. Shang. 2023. “Biophysical Mechanisms Underlying the Effects of Static Magnetic Fields on Biological Systems.” Progress in Biophysics and Molecular Biology 177: 14–23.
Zhang, H., L. Gan, X. Zhu, et al. 2018. “Moderate‐Intensity 4mT Static Magnetic Fields Prevent Bone Architectural Deterioration and Strength Reduction by Stimulating Bone Formation in Streptozotocin‐Treated Diabetic Rats.” Bone 107: 36–44.
Zhang, J., X. Meng, C. Ding, and P. Shang. 2018. “Effects of Static Magnetic Fields on Bone Microstructure and Mechanical Properties in Mice.” Electromagnetic Biology and Medicine 37: 76–83.
Caliogna, L., V. Bina, A. M. Brancato, et al. 2022. “The Role of PEMFs on Bone Healing: An In Vitro Study.” International Journal of Molecular Sciences 23: 14298.
Caliogna, L., M. Medetti, V. Bina, et al. 2021. “Pulsed Electromagnetic Fields in Bone Healing: Molecular Pathways and Clinical Applications.” International Journal of Molecular Sciences 22: 7403.
Clézardin, P., R. Coleman, M. Puppo, et al. 2021. “Bone Metastasis: Mechanisms, Therapies, and Biomarkers.” Physiological Reviews 101: 797–855.
Compston, J. E., M. R. McClung, and W. D. Leslie. 2019. “Osteoporosis.” Lancet 393: 364–376.
Degen, I. L., and V. I. Stetsula. 1971. “[Consolidation of Bone Fragments in a Constant Magnetic Field].” Ortopediia Travmatologiia i Protezirovanie 32: 45–48.
Durmus, N. G., H. C. Tekin, S. Guven, et al. 2015. “Magnetic Levitation of Single Cells.” Proceedings of the National Academy of Sciences 112: E3661–E3668.
Fischer, V., and M. Haffner‐Luntzer. 2022. “Interaction Between Bone and Immune Cells: Implications for Postmenopausal Osteoporosis.” Seminars in Cell & Developmental Biology 123: 14–21.
Hosseini, S., H. Parsaei, M. Moosavifar, N. Tavakoli, R. Ahadi, and K. Roshanbinfar. 2024. “Static Magnetic Field Enhances the Bone Remodelling Capacity of Human Demineralized Bone Matrix in a Rat Animal Model of Cranial Bone Defects.” Journal of Materials Chemistry B 12: 3774–3785.
Houpt, T. A., and C. E. Houpt. 2010. “Circular Swimming in Mice After Exposure to a High Magnetic Field.” Physiology & Behavior 100: 284–290.
Houpt, T. A., D. W. Pittman, J. M. Barranco, E. H. Brooks, and J. C. Smith. 2003. “Behavioral Effects of High‐Strength Static Magnetic Fields on Rats.” Journal of Neuroscience 23: 1498–1505.
Kim, E. C., R. Leesungbok, S. W. Lee, et al. 2015. “Effects of Moderate Intensity Static Magnetic Fields on Human Bone Marrow‐Derived Mesenchymal Stem Cells.” Bioelectromagnetics 36: 267–276.
Kim, E. C., J. Park, G. Noh, et al. 2018. “Effects of Moderate Intensity Static Magnetic Fields on Osteoclastic Differentiation in Mouse Bone Marrow Cells.” Bioelectromagnetics 39: 394–404.
Kotani, H., H. Kawaguchi, T. Shimoaka, et al. 2002. “Strong Static Magnetic Field Stimulates Bone Formation to a Definite Orientation In Vitro and In Vivo.” Journal of Bone and Mineral Research 17: 1814–1821.
De Luka, S. R., A. Ž. Ilić, S. Janković, et al. 2016. “Subchronic Exposure to Static Magnetic Field Differently Affects Zinc and Copper Content in Murine Organs.” International Journal of Radiation Biology 92: 140–147.
Milovanovich, I. D., S. Ćirković, S. R. De Luka, et al. 2016. “Homogeneous Static Magnetic Field of Different Orientation Induces Biological Changes in Subacutely Exposed Mice.” Environmental Science and Pollution Research 23: 1584–1597.
Minoia, A., L. Dalle Carbonare, J. C. Schwamborn, S. Bolognin, and M. T. Valenti. 2022. “Bone Tissue and the Nervous System: What Do They Have in Common?” Cells 12: 51.
Morgan, E. F., G. U. Unnikrisnan, and A. I. Hussein. 2018. “Bone Mechanical Properties in Healthy and Diseased States.” Annual Review of Biomedical Engineering 20: 119–143.
Oftadeh, R., M. Perez‐Viloria, J. C. Villa‐Camacho, A. Vaziri, and A. Nazarian. 2015. “Biomechanics and Mechanobiology of Trabecular Bone: A Review.” Journal of Biomechanical Engineering 137: 0108021–01080215.
Roberts, D. C., V. Marcelli, J. S. Gillen, J. P. Carey, C. C. Della Santina, and D. S. Zee. 2011. “MRI Magnetic Field Stimulates Rotational Sensors of the Brain.” Current Biology 21: 1635–1640.
Song, C., H. Chen, B. Yu, et al. 2023. “Magnetic Fields Affect Alcoholic Liver Disease by Liver Cell Oxidative Stress and Proliferation Regulation.” Research A Journal of Science and Its Applications 6: 0097.
Song, S., Y. Guo, Y. Yang, and D. Fu. 2022. “Advances in Pathogenesis and Therapeutic Strategies for Osteoporosis.” Pharmacology & Therapeutics 237: 108168.
Tasic, T., M. Lozić, S. Glumac, et al. 2021. “Static Magnetic Field on Behavior, Hematological Parameters and Organ Damage in Spontaneously Hypertensive Rats.” Ecotoxicology and Environmental Safety 207: 111085.
Tian, X., D. Wang, M. Zha, et al. 2018. “Magnetic Field Direction Differentially Impacts the Growth of Different Cell Types.” Electromagnetic Biology and Medicine 37: 114–125.
Walker, M. D., and E. Shane. 2023. “Postmenopausal Osteoporosis.” New England Journal of Medicine 389: 1979–1991.
Wang, S., Y. Liu, C. Lou, et al. 2023. “Moderate Static Magnetic Field Promotes Fracture Healing and Regulates Iron Metabolism in Mice.” Biomedical Engineering Online 22: 107.
Wiltschko, W., and R. Wiltschko. 2005. “Magnetic Orientation and Magnetoreception in Birds and Other Animals.” Journal of Comparative Physiology A 191: 675–693.
Wu, A. M., C. Bisignano, S. L. James, et al. 2021. “Global, Regional, and National Burden of Bone Fractures in 204 Countries and Territories, 1990–2019: A Systematic Analysis From the Global Burden of Disease Study 2019.” Lancet Healthy Longevity 2: e580–e592.
Xie, W., C. Song, R. Guo, and X. Zhang. 2024. “Static Magnetic Fields in Regenerative Medicine.” APL Bioengineering 8: 011503.
Yang, J., S. Zhou, M. Wei, Y. Fang, and P. Shang. 2021. “Moderate Static Magnetic Fields Prevent Bone Architectural Deterioration and Strength Reduction in Ovariectomized Mice.” IEEE Transactions on Magnetics 57: 1–9.
Yu, B., J. Liu, J. Cheng, et al. 2021. “A Static Magnetic Field Improves Iron Metabolism and Prevents High‐Fat‐Diet/Streptozocin‐Induced Diabetes.” Innovation 2: 100077.
Zhang, B., X. Yuan, H. Lv, J. Che, S. Wang, and P. Shang. 2023. “Biophysical Mechanisms Underlying the Effects of Static Magnetic Fields on Biological Systems.” Progress in Biophysics and Molecular Biology 177: 14–23.
Zhang, H., L. Gan, X. Zhu, et al. 2018. “Moderate‐Intensity 4mT Static Magnetic Fields Prevent Bone Architectural Deterioration and Strength Reduction by Stimulating Bone Formation in Streptozotocin‐Treated Diabetic Rats.” Bone 107: 36–44.
Zhang, J., X. Meng, C. Ding, and P. Shang. 2018. “Effects of Static Magnetic Fields on Bone Microstructure and Mechanical Properties in Mice.” Electromagnetic Biology and Medicine 37: 76–83.
Grant Information:
JCYJ20230807144159004 The Shenzhen Science and Technology Program; 2022A1515110171 Guangdong Basic and Applied Basic Research Foundation; 52037007 National Natural Science Foundation of China
Contributed Indexing:
Keywords: bone loss; moderate static magnetic field; orientation; ovariectomized mice
Substance Nomenclature:
0 (Biomarkers)
Entry Date(s):
Date Created: 20251222 Date Completed: 20251222 Latest Revision: 20251222
Update Code:
20251222
DOI:
10.1002/bem.70037
PMID:
41424392
Database:
MEDLINE
Weitere Informationen
Various studies have indicated that moderate static magnetic fields (MMFs) could inhibit bone loss and facilitate bone fracture healing. The biological effects of static magnetic fields vary depending on their orientation. Herein, we investigated the effects of MMF in different orientations on bone loss in ovariectomized (OVX) mice. The OVX mice were exposed to 20-100 mT MMFs with magnetic field lines oriented in the N-upward and S-upward directions for 8 weeks, respectively. Then, the bone mass, microarchitecture, mechanical properties, and turnover markers were evaluated. The results showed that both N-upward and S-upward MMFs exposure prevented the decrease of bone mineral density (BMD) and bone mineral content (BMC) induced by OVX, improved the bone microstructure, and enhanced the bone mechanical properties. The serum bone formation markers propeptide of type I procollagen (P1NP) and osteocalcin (OCN) have been increased by MMFs exposure, while bone resorption marker beta-isomer of the C-terminal telopeptide of type I collagen (β-CTX) has been decreased by MMFs exposure in OVX mice. Meanwhile, MMFs exposure decreased osteoclast distribution on the surface of trabecular bone and cortical bone. N-upward MMF exposure increased osteoblast number per bone surface (N.Ob/BS) in trabecular bone. Moreover, mice under N-upward orientation MMFs exposure exhibited higher stiffness, elastic modulus, and total energy absorption in terms of tibial mechanical properties compared to S-upward orientation MMFs exposure. In conclusion, these results demonstrate that 20-100 mT MMFs exposure with different orientations suppressed the ovariectomized-induced bone loss and mechanical properties degradation in mice, and the N-upward MMFs hold superior effects.
(© 2025 Bioelectromagnetics Society.)