• Microbubble Formation and Hemo...

Treffer: Microbubble Formation and Hemolysis in Pulsed Field Ablation for Treating Arrhythmia: Risks, Mechanisms, and Prevention.

Title:
Microbubble Formation and Hemolysis in Pulsed Field Ablation for Treating Arrhythmia: Risks, Mechanisms, and Prevention.
Authors:
Ranjbartehrani P; Synaptic Medical, Carlsbad, California, USA.
Source:
Pacing and clinical electrophysiology : PACE [Pacing Clin Electrophysiol] 2026 Jan; Vol. 49 (1), pp. 52-57. Date of Electronic Publication: 2025 Dec 05.
Publication Type:
Journal Article; Review
Language:
English
Journal Info:
Publisher: Futura Pub. Co. Country of Publication: United States NLM ID: 7803944 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-8159 (Electronic) Linking ISSN: 01478389 NLM ISO Abbreviation: Pacing Clin Electrophysiol Subsets: MEDLINE
Imprint Name(s):
Original Publication: Mount Kisco, N. Y. : Futura Pub. Co., c1978-
MeSH Terms:
Hemolysis* , Microbubbles*/adverse effects , Catheter Ablation*/adverse effects , Catheter Ablation*/methods , Arrhythmias, Cardiac*/surgery, Humans
References:
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Contributed Indexing:
Keywords: arrythmia; cardiac ablation; hemolysis; microbubbles; pulsed field ablation
Entry Date(s):
Date Created: 20251205 Date Completed: 20260119 Latest Revision: 20260121
Update Code:
20260121
PubMed Central ID:
PMC12813644
DOI:
10.1111/pace.70035
PMID:
41347755
Database:
MEDLINE

Weitere Informationen

Pulsed Field Ablation (PFA) is an emerging energy modality for cardiac ablation, offering shorter atrial dwell times and reduced collateral damage compared to thermal methods. However, energy-related complications, specifically gaseous microbubble formation and hemolysis, require further evaluation. Microbubble formation, driven by electrolysis, boiling, and degassing, poses a potential risk for embolic events. Similarly, hemolysis results from unintended energy dissipation into the bloodstream, affecting kidney function. Both complications can be mitigated through optimized waveform and catheter design and other procedural strategies. Enhancing PFA safety requires a deeper understanding of its biophysical interactions and continuous refinement of ablation protocols to minimize risks while preserving clinical efficacy.
(© 2025 The Author(s). Pacing and Clinical Electrophysiology published by Wiley Periodicals LLC.)