Treffer: Nanosize Polymeric Foams and Microparticles Prepared In Situ From Janus-Type Microbubble Constitutions.
Title:
Nanosize Polymeric Foams and Microparticles Prepared In Situ From Janus-Type Microbubble Constitutions.
Authors:
Yesilyurt T; Center for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, Istanbul, Turkey.; Department of Bioengineering, Faculty of Chemistry and Metallurgy, Yıldız Technical University, Istanbul, Turkey., Cesur S; Center for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, Istanbul, Turkey.; Department of Metallurgical and Materials Engineering, Faculty of Technology, Marmara University, Istanbul, Turkey., Alptürk O; Department of Chemistry, Faculty of Science and Literature, İstanbul Technical University, Istanbul, Turkey., Arısan ED; Department of Molecular Biology and Genetics, Gebze Technical University, Istanbul, Turkey., Obakan P; Department of Molecular Biology and Genetics, Medeniyet University, Istanbul, Turkey., Evran S; Department of Jewelry and Jewelry Design, Faculty of Applied Sciences, Marmara University, Istanbul, Turkey., Gunduz O; Center for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, Istanbul, Turkey.; Department of Metallurgical and Materials Engineering, Faculty of Technology, Marmara University, Istanbul, Turkey.; Health Biotechnology Joint Research and Application Center of Excellence, Istanbul, Türkiye., Özerol E; Department of Bioengineering, Faculty of Chemistry and Metallurgy, Yıldız Technical University, Istanbul, Turkey.; Health Biotechnology Joint Research and Application Center of Excellence, Istanbul, Türkiye., Narayan R; Department of Biomedical Engineering, North Carolina State University, Raleigh, North Carolina, USA., Ustundag CB; Center for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, Istanbul, Turkey.; Department of Bioengineering, Faculty of Chemistry and Metallurgy, Yıldız Technical University, Istanbul, Turkey.; Health Biotechnology Joint Research and Application Center of Excellence, Istanbul, Türkiye.
Source:
Journal of biomedical materials research. Part B, Applied biomaterials [J Biomed Mater Res B Appl Biomater] 2025 Dec; Vol. 113 (12), pp. e70006.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101234238 Publication Model: Print Cited Medium: Internet ISSN: 1552-4981 (Electronic) Linking ISSN: 15524973 NLM ISO Abbreviation: J Biomed Mater Res B Appl Biomater Subsets: MEDLINE
Imprint Name(s):
Original Publication: Hoboken, NJ : John Wiley & Sons, c2003-
MeSH Terms:
References:
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A. Delama, M. I. Teixeira, R. Dorati, I. Genta, B. Conti, and D. A. Lamprou, “Microfluidic Encapsulation Method to Produce Stable Liposomes Containing Iohexol,” Journal of Drug Delivery Science and Technology 54 (2019): 101340.
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H. Xie, Z. G. She, S. Wang, G. Sharma, and J. W. Smith, “One‐Step Fabrication of Polymeric Janus Nanoparticles for Drug Delivery,” Langmuir 28, no. 9 (2012): 4459–4463.
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P. Caliceti, S. Salmaso, N. Elvassore, and A. Bertucco, “Effective Protein Release from PEG/PLA Nano‐Particles Produced by Compressed Gas Anti‐Solvent Precipitation Techniques,” Journal of Controlled Release 94, no. 1 (2004): 195–205.
E. Chiesa, A. Greco, R. Dorati, et al., “Microfluidic‐Assisted Synthesis of Multifunctional Iodinated Contrast Agent Polymeric Nanoplatforms,” International Journal of Pharmaceutics 599, no. March (2021): 120447.
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S. Pal and C. Saha, “Solvent Effect in the Synthesis of Hydrophobic Drug‐Loaded Polymer Nanoparticles,” IET Nanobiotechnology 11, no. 4 (2017): 443–447.
A. Rezaei and M. R. Mohammadi, “In Vitro Study of Hydroxyapatite/Polycaprolactone (HA/PCL) Nanocomposite Synthesized by an in Situ Sol–Gel Process,” Materials Science and Engineering: C 33, no. 1 (2013): 390–396.
R. Haggerty, D. Zhang, J. Eun, and Y. Li, “Characterization of Bubble Transport in Porous Media Using a Microfluidic Channel,” Water 15, no. 6 (2023): 1033.
D. V. Tomasino, M. Wolf, H. Farina, et al., Polymers 13, no. 4 (2021): 658.
T. Bedir, S. Ulag, K. Aydogan, et al., “Role of Doping Agent Degree of Sulfonation and Casting Solvent on the Electrical Conductivity and Morphology of PEDOT: SPAES thin Films,” Polymers for Advanced Technologies 32, no. 3 (2021): 1114–1125.
S. Harmanci, A. Dutta, S. Cesur, et al., “Production of 3D Printed bi‐Layer and Tri‐Layer Sandwich Scaffolds With Polycaprolactone and Poly (Vinyl Alcohol)‐Metformin Towards Diabetic Wound Healing,” Polymers 14, no. 23 (2022): 5306.
S. Yamane, S. Ata, L. Chen, et al., “Experimental Analysis of Stabilizing Effects of Carbon Nanotubes (CNTs) on Thermal Oxidation of Poly(Ethylene Glycol)–CNT Composites,” Chemical Physics Letters 670 (2017): 32–36.
S. Khoee and M. Jalaeian Bashirzadeh, “Preparation of Janus‐Type Superparamagnetic Iron Oxide Nanoparticles Modified With Functionalized PCL / PHEMA via Photopolymerization for Dual Drug Delivery,” Journal of Applied Polymer Science 138, no. 1 (2020): 49627.
L. Xu, Z. Chu, H. Wang, et al., “Electrostatically Assembled Multilayered Films of Biopolymer Enhanced Nanocapsules for On‐Demand Drug Release,” ACS Applied Bio Materials 2, no. 8 (2019): 3429–3438.
G. Zhang, X. Wang, Z. Wang, J. Zhang, and L. Suggs, “A PEGylated Fibrin Patch for Mesenchymal Stem Cell Delivery,” Tissue Engineering 12, no. 1 (2006): 9–19.
H. Smith, Z. Xie, G. She, S. Wang, and G. Sharma, “One‐Step Fabrication of Polymeric Janus Nanoparticles for Drug Delivery,” Langmuir 28, no. 9 (2012): 4459–4463.
T. Maric, M. Z. M. Nasir, R. D. Webster, and M. Pumera, “Tailoring Metal/TiO2 Interface to Influence Motion of Light‐Activated Janus Micromotors,” Advanced Functional Materials 1908614 (2020): 1908614.
M. Oishi and Y. Nagasaki, “Synthesis, Characterization, and Biomedical Applications of Core–Shell‐Type Stimuli‐Responsive Nanogels–Nanogel Composed of Poly [2‐(N, N‐diethylamino) Ethyl Methacrylate] Core and PEG Tethered Chains,” Reactive Functions and Programming 67, no. 11 (2007): 1311–1329.
E. E. Ekanem, S. A. Nabavi, G. T. Vladisavljević, and S. Gu, “Structured Biodegradable Polymeric Microparticles for Drug Delivery Produced Using Flow Focusing Glass Microfluidic Devices,” ACS Applied Materials & Interfaces 7, no. 41 (2015): 23132–23143.
A. Delama, M. I. Teixeira, R. Dorati, I. Genta, B. Conti, and D. A. Lamprou, “Microfluidic Encapsulation Method to Produce Stable Liposomes Containing Iohexol,” Journal of Drug Delivery Science and Technology 54 (2019): 101340.
P. Zhao, J. Wang, Y. Li, X. Wang, C. Chen, and G. Liu, “Microfluidic Technology for the Production of Well‐Ordered Porous Polymer Scaffolds,” Polymers 12 (2020): 9.
H. Xie, Z. G. She, S. Wang, G. Sharma, and J. W. Smith, “One‐Step Fabrication of Polymeric Janus Nanoparticles for Drug Delivery,” Langmuir 28, no. 9 (2012): 4459–4463.
Z. Ekemen, H. Chang, Z. Ahmad, et al., “Fabrication of Biomaterials via Controlled Protein Bubble Generation and Manipulation,” Biomacromolecules 12, no. 12 (2011): 4291–4300.
K. Pancholi, E. Stride, and M. Edirisinghe, “Generation of Microbubbles for Diagnostic and Therapeutic Applications Using a Novel Device,” Journal of Drug Targeting 16, no. 6 (2008): 494–501.
Ansys Fluent 12.0 Theory Guide (ANSYS Inc, 2009).
Z. R. Ege, A. Akan, F. N. Oktar, C. C. Lin, B. Karademir, and O. Gunduz, “Encapsulation of Indocyanine Green in Poly (lactic acid) Nanofibers for Using as a Nanoprobe in biomedical Diagnostic,” Materials Letters 228 (2018): 148–151.
P. Caliceti, S. Salmaso, N. Elvassore, and A. Bertucco, “Effective Protein Release from PEG/PLA Nano‐Particles Produced by Compressed Gas Anti‐Solvent Precipitation Techniques,” Journal of Controlled Release 94, no. 1 (2004): 195–205.
E. Chiesa, A. Greco, R. Dorati, et al., “Microfluidic‐Assisted Synthesis of Multifunctional Iodinated Contrast Agent Polymeric Nanoplatforms,” International Journal of Pharmaceutics 599, no. March (2021): 120447.
A. Tampau, C. González‐Martínez, A. A. Vicente, and A. Chiralt, “Enhancement of PLA‐PVA,” Food and Bioprocess Technology 13, no. 7 (2020): 1228.
J. Ren, H. Hong, T. Ren, and X. Teng, “Preparation and Characterization of Magnetic PLA–PEG Composite Nanoparticles for Drug Targeting,” Reactive and Functional Polymers 66, no. 9 (2006): 944–951.
X. Zhang, Q. Fu, H. Duan, J. Song, and H. Yang, “Janus Nanoparticles: From Fabrication to (bio) Applications,” ACS Nano 15, no. 4 (2021): 6147–6191.
S. Bärwinkel, R. Bahrami, T. I. Löbling, H. Schmalz, A. H. E. Müller, and V. Altstädt, “Polymer Foams Made of Immiscible Polymer Blends Compatibilized by Janus Particles—Effect of Compatibilization on Foam Morphology,” Advanced Engineering Materials 18 (2016): 814–825.
S. Pal and C. Saha, “Solvent Effect in the Synthesis of Hydrophobic Drug‐Loaded Polymer Nanoparticles,” IET Nanobiotechnology 11, no. 4 (2017): 443–447.
A. Rezaei and M. R. Mohammadi, “In Vitro Study of Hydroxyapatite/Polycaprolactone (HA/PCL) Nanocomposite Synthesized by an in Situ Sol–Gel Process,” Materials Science and Engineering: C 33, no. 1 (2013): 390–396.
R. Haggerty, D. Zhang, J. Eun, and Y. Li, “Characterization of Bubble Transport in Porous Media Using a Microfluidic Channel,” Water 15, no. 6 (2023): 1033.
D. V. Tomasino, M. Wolf, H. Farina, et al., Polymers 13, no. 4 (2021): 658.
T. Bedir, S. Ulag, K. Aydogan, et al., “Role of Doping Agent Degree of Sulfonation and Casting Solvent on the Electrical Conductivity and Morphology of PEDOT: SPAES thin Films,” Polymers for Advanced Technologies 32, no. 3 (2021): 1114–1125.
S. Harmanci, A. Dutta, S. Cesur, et al., “Production of 3D Printed bi‐Layer and Tri‐Layer Sandwich Scaffolds With Polycaprolactone and Poly (Vinyl Alcohol)‐Metformin Towards Diabetic Wound Healing,” Polymers 14, no. 23 (2022): 5306.
S. Yamane, S. Ata, L. Chen, et al., “Experimental Analysis of Stabilizing Effects of Carbon Nanotubes (CNTs) on Thermal Oxidation of Poly(Ethylene Glycol)–CNT Composites,” Chemical Physics Letters 670 (2017): 32–36.
S. Khoee and M. Jalaeian Bashirzadeh, “Preparation of Janus‐Type Superparamagnetic Iron Oxide Nanoparticles Modified With Functionalized PCL / PHEMA via Photopolymerization for Dual Drug Delivery,” Journal of Applied Polymer Science 138, no. 1 (2020): 49627.
Contributed Indexing:
Keywords: Janus microbubbles; VJM junction; microfluidics; morphological pattern; numerical analysis
Substance Nomenclature:
3WJQ0SDW1A (Polyethylene Glycols)
0 (Polyesters)
459TN2L5F5 (poly(lactide))
0 (Polyesters)
459TN2L5F5 (poly(lactide))
Entry Date(s):
Date Created: 20251129 Date Completed: 20251129 Latest Revision: 20251129
Update Code:
20251129
DOI:
10.1002/jbmb.70006
PMID:
41316837
Database:
MEDLINE
Weitere Informationen
In this work, we generate Janus-type microbubbles that have distinct morphological patterns by utilizing microfluidics technology. A V-Junction Microfluidic (VJM) device was designed through a Solidworks program with three inlets and one microfluidic outlet attached at 30° to produce a closed system. 3% wt. PLA and 3% wt. PEG were chosen owing to the distinct physicochemical features of these polymers. Two hundred and seventy-five microliters/min PLA and 180 μL/min PEG were fed into the system with a nitrogen gas pressure of 12 kPa, where five different solvents produced Janus-type microbubbles. In addition, the effect of the change in inlet velocity of nitrogen gas on the composition of the solutions, volume fraction, and density changes was numerically examined. The results indicate that honeycomb structures and particle formation were observed at different scales, ranging from 854 ± 49 nm to 6.5 ± 0.5 μm. Numerical analysis showed that the speed associated with the 3 wt.% PLA and 3 wt.% PEG solutions had a direct effect on phase formation. Numerical results also showed that the difference in the inlet velocity of nitrogen gas in the apparatus can play a significant role in the composition of the solutions; this change may also affect the formation of microbubbles.
(© 2025 The Author(s). Journal of Biomedical Materials Research Part B: Applied Biomaterials published by Wiley Periodicals LLC.)