• Miniaturized low-field thoraci...

Treffer: Miniaturized low-field thoracic magnetic stimulation device for assessing effects on peripheral oxygen saturation levels in healthy rats.

Title:
Miniaturized low-field thoracic magnetic stimulation device for assessing effects on peripheral oxygen saturation levels in healthy rats.
Authors:
Moreno J; Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, 14 Sur 6301, Colonia San Manuel, Apartado Postal 406, CP 72570, Puebla, Puebla, Mexico., Dominguez-Nicolas SM; Centro de Investigación de Micro y Nanotecnología, and Facultad de Ingeniería Eléctrica, Universidad Veracruzana, Calzada Ruiz Cortines 455 Boca del Rio, Veracruz 94294, Mexico., Gutierrez J; Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, 14 Sur 6301, Colonia San Manuel, Apartado Postal 406, CP 72570, Puebla, Puebla, Mexico., Flores A; Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, 14 Sur 6301, Colonia San Manuel, Apartado Postal 406, CP 72570, Puebla, Puebla, Mexico., Manjarrez E; Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, 14 Sur 6301, Colonia San Manuel, Apartado Postal 406, CP 72570, Puebla, Puebla, Mexico.
Source:
Biomedical physics & engineering express [Biomed Phys Eng Express] 2025 Dec 05; Vol. 12 (1). Date of Electronic Publication: 2025 Dec 05.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: IOP Publishing Ltd Country of Publication: England NLM ID: 101675002 Publication Model: Electronic Cited Medium: Internet ISSN: 2057-1976 (Electronic) Linking ISSN: 20571976 NLM ISO Abbreviation: Biomed Phys Eng Express Subsets: MEDLINE
Imprint Name(s):
Original Publication: Bristol : IOP Publishing Ltd., [2015]-
MeSH Terms:
Oxygen Saturation* , Oxygen*/metabolism , Oxygen*/blood , Miniaturization* , Magnetic Fields*, Animals ; Rats ; Male ; Rats, Sprague-Dawley ; Equipment Design ; COVID-19 ; Electromagnetic Fields ; SARS-CoV-2 ; Oximetry ; Humans
Contributed Indexing:
Keywords: low-field thoracic magnetic stimulation (LF-ThMS); magnetic stimulation device; miniaturized LF-ThMS device; peripheral oxygen saturation; pulse oximeter; pulsed electromagnetic field (PEMF) device
Substance Nomenclature:
S88TT14065 (Oxygen)
Entry Date(s):
Date Created: 20251126 Date Completed: 20251205 Latest Revision: 20251205
Update Code:
20251205
DOI:
10.1088/2057-1976/ae2489
PMID:
41297067
Database:
MEDLINE

Weitere Informationen

Objective. This study aimed to develop a miniaturized low-field thoracic magnetic stimulation (LF-ThMS) device to evaluate its effects on peripheral oxygen saturation (SpO <subscript>2</subscript> ) in healthy rats. This investigation was motivated by prior findings that LF-ThMS at 10.5 to 13.1 mT increased SpO <subscript>2</subscript> in patients with COVID-19. However, its effect on healthy subjects remains unknown. To address this gap before extending research to healthy humans, we first examined its effects in healthy animal models. Approach. A miniature low-field thoracic magnetic stimulation (LF-ThMS) device, also referred to as a pulsed electromagnetic field (PEMF) system, was developed using two 30-turn coils made of 13-gauge magnet wire, encased in nylon sheaths. The coils were powered by a 30 V, 13 A DC source to generate magnetic pulses up to 13.1 mT. A custom control circuit, featuring an ATmega328P microcontroller, relays, and MOSFETs, regulated the pulse frequency and included a safety system to maintain coil temperatures below 38 °C. The device also featured a user interface for customizable and reproducible operation. Peripheral oxygen saturation (SpO <subscript>2</subscript> ) was monitored using a NONIN 750 pulse oximeter. Main results. The LF-ThMS device successfully generated magnetic flux densities of 10.5, 11.6, and 13.1 mT. However, when we compared SpO <subscript>2</subscript> levels between the control condition (before LF-ThMS) and the SpO <subscript>2</subscript> levels after the LF-ThMS at these intensities, we did not find a statistically significant difference. S ignificance. These results suggest that LF-ThMS may not affect SpO <subscript>2</subscript> in healthy individuals, and the improvements observed in COVID-19 patients could be due to disease-specific mechanisms or other unknown factors, rather than a general physiological effect of LF-ThMS.
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