• Paclitaxel and rose bengal loa...

Treffer: Paclitaxel and rose bengal loaded microbubbles for the ultrasound targeted chemo-sonodynamic therapy of pancreatic cancer.

Title:
Paclitaxel and rose bengal loaded microbubbles for the ultrasound targeted chemo-sonodynamic therapy of pancreatic cancer.
Authors:
Wright J; Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland, UK., Logan K; Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland, UK., McKaig T; Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland, UK., Kamila S; Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland, UK., McClenaghan C; Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland, UK., Nesbitt H; Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland, UK., Taylor MA; Department of HPB Surgery, Mater Hospital, Belfast BT14 6AB Northern Ireland, UK., Love M; Imaging Centre, The Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BA Northern Ireland, UK., Stride E; Institute of Biomedical Engineering, University of Oxford, Oxford OX3 7DQ, UK., Ruan JL; Institute of Biomedical Engineering, University of Oxford, Oxford OX3 7DQ, UK., McHale AP; Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland, UK., Callan JF; Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland, UK. Electronic address: j.callan@ulster.ac.uk.
Source:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2026 Jan; Vol. 218, pp. 114937. Date of Electronic Publication: 2025 Nov 19.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9109778 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3441 (Electronic) Linking ISSN: 09396411 NLM ISO Abbreviation: Eur J Pharm Biopharm Subsets: MEDLINE
Imprint Name(s):
Publication: Amsterdam : Elsevier Science
Original Publication: Stuttgart : Wissenschaftliche Verlagsgesellschaft, c1991-
MeSH Terms:
Paclitaxel*/administration & dosage , Rose Bengal*/administration & dosage , Rose Bengal*/chemistry , Pancreatic Neoplasms*/drug therapy , Microbubbles* , Ultrasonic Therapy*/methods, Animals ; Mice ; Drug Delivery Systems/methods ; Cell Line, Tumor ; Humans ; Female ; Antineoplastic Agents, Phytogenic/administration & dosage ; Ultrasonography
Contributed Indexing:
Keywords: MBs; Paclitaxel; Pancreatic cancer; Rose bengal; Targeted therapy; Ultrasound
Substance Nomenclature:
P88XT4IS4D (Paclitaxel)
1ZPG1ELY14 (Rose Bengal)
0 (Antineoplastic Agents, Phytogenic)
Entry Date(s):
Date Created: 20251121 Date Completed: 20251207 Latest Revision: 20251207
Update Code:
20251208
DOI:
10.1016/j.ejpb.2025.114937
PMID:
41270840
Database:
MEDLINE

Weitere Informationen

Despite significant advances in cancer treatment over the past five decades, survival outcomes for pancreatic cancer have remained largely unchanged. The effectiveness of chemotherapy as a treatment for pancreatic cancer is limited by the dense, protective tumour stroma, which impedes drug delivery. Ultrasound-targeted microbubble destruction (UTMD) has emerged as a promising strategy for enhancing the delivery of chemotherapy agents to solid tumours. In this study, we report the development and evaluation of a novel microbubble (MB) formulation, ST-001, which incorporates paclitaxel chemotherapy and a Rose Bengal sonosensitiser for targeted chemo-sonodynamic therapy of pancreatic cancer. The principle of UTMD using ST-001 was demonstrated in a murine model of pancreatic cancer, where B-mode ultrasound imaging was used to visualize MB accumulation within the tumour and its subsequent clearance following the application of therapeutic ultrasound. Preclinical efficacy studies demonstrated a significant survival advantage in ST-001 treated mice, which survived more than twice as long as those treated with standard Taxol, despite receiving only 14% of the paclitaxel dose. Additionally, a preclinical toxicology study in healthy mice demonstrated an excellent safety profile for ST-001, with no adverse effects observed in key hematological and blood biochemical markers, or in the histology of the spleen, liver, and kidneys.
(Copyright © 2025 Elsevier B.V. All rights reserved.)

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: J.C, A.McH, E.S and M.A.T are co-founders of SonoTarg Ltd.