• The Incremental Yield of CMA O...

Treffer: The Incremental Yield of CMA Over Karyotype in Fetal Growth Restriction-A Systematic Review and Meta-Analysis.

Title:
The Incremental Yield of CMA Over Karyotype in Fetal Growth Restriction-A Systematic Review and Meta-Analysis.
Authors:
Sapantzoglou I; 1st Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece., Kontogeorgi E; 1st Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece., Pergialiotis V; 1st Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece., Tasias K; 1st Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece., Rouvali A; 1st Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece., Pegkou A; 1st Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece., Theodora M; 1st Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece., Daskalakis G; 1st Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece., Antsaklis P; 1st Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Source:
Prenatal diagnosis [Prenat Diagn] 2026 Jan; Vol. 46 (1), pp. 56-74. Date of Electronic Publication: 2025 Nov 14.
Publication Type:
Journal Article; Meta-Analysis; Systematic Review
Language:
English
Journal Info:
Publisher: Wiley Country of Publication: England NLM ID: 8106540 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0223 (Electronic) Linking ISSN: 01973851 NLM ISO Abbreviation: Prenat Diagn Subsets: MEDLINE
Imprint Name(s):
Original Publication: Chichester, [Sussex]; New York : Wiley, c1981-
MeSH Terms:
Fetal Growth Retardation*/genetics , Fetal Growth Retardation*/diagnosis , Karyotyping*/methods , Microarray Analysis*/methods, Female ; Humans ; Pregnancy ; Karyotype
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Entry Date(s):
Date Created: 20251114 Date Completed: 20260121 Latest Revision: 20260123
Update Code:
20260123
PubMed Central ID:
PMC12819929
DOI:
10.1002/pd.70022
PMID:
41238525
Database:
MEDLINE

Weitere Informationen

The main objective of our study was to conduct a systematic literature review and a meta-analysis to evaluate the incremental yield of chromosomal microarray analysis compared with karyotyping in cases of fetal growth restriction. Our review was designed according to the PRISMA guidelines. It included all observational studies that reported the results of CMA testing in fetuses diagnosed with growth restriction without additional findings (isolated FGR), with structural abnormalities (malformed FGR) and with the presence of additional findings that would not qualify as structural abnormalities (nonmalformed FGR). The study included 22 studies with a total of 2275 cases of affected fetuses that met the inclusion criteria for analysis. Combined data from these studies revealed an overall 3% incremental yield of CMA over karyotyping (95% CI 2%-5%) in isolated cases, an overall 4% incremental yield of CMA over karyotyping (95% CI 3%-5%) in nonmalformed FGR cases and an overall 10% incremental yield (95% CI -13%) in malformed FGR cases. Our findings may be useful in clinical practice to guide management options and the counseling of the couples to individualize patient care and facilitate clinicians when they come across such a common clinical entity.
(© 2025 The Author(s). Prenatal Diagnosis published by John Wiley & Sons Ltd.)