Treffer: Alteration of Essential Cell Function by Ultrasound-Targeted Microbubble Cavitation.
Title:
Alteration of Essential Cell Function by Ultrasound-Targeted Microbubble Cavitation.
Authors:
Paranjape AN; Center for Ultrasound Molecular Imaging and Therapeutics, Heart and Vascular Institute, University of Pittsburgh, Pittsburgh, PA, 15213, USA., Chen X; Center for Ultrasound Molecular Imaging and Therapeutics, Heart and Vascular Institute, University of Pittsburgh, Pittsburgh, PA, 15213, USA., Villanueva FS; Center for Ultrasound Molecular Imaging and Therapeutics, Heart and Vascular Institute, University of Pittsburgh, Pittsburgh, PA, 15213, USA. villanuevafs@upmc.edu.
Source:
Current cardiology reports [Curr Cardiol Rep] 2025 Nov 14; Vol. 27 (1), pp. 155. Date of Electronic Publication: 2025 Nov 14.
Publication Type:
Journal Article; Review
Language:
English
Journal Info:
Publisher: Current Science Country of Publication: United States NLM ID: 100888969 Publication Model: Electronic Cited Medium: Internet ISSN: 1534-3170 (Electronic) Linking ISSN: 15233782 NLM ISO Abbreviation: Curr Cardiol Rep Subsets: MEDLINE
Imprint Name(s):
Original Publication: Philadelphia, PA : Current Science, c1999-
MeSH Terms:
References:
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Grant Information:
R01EB026966 United States NH NIH HHS
Contributed Indexing:
Keywords: Bioeffects; Calcium; Drug delivery; Endothelial cells; Microbubbles; Ultrasound
Substance Nomenclature:
SY7Q814VUP (Calcium)
Entry Date(s):
Date Created: 20251114 Date Completed: 20251114 Latest Revision: 20251114
Update Code:
20251114
DOI:
10.1007/s11886-025-02278-9
PMID:
41236581
Database:
MEDLINE
Weitere Informationen
Purpose of Review: Ultrasound-targeted microbubble cavitation (UTMC) has emerged as a transformative non-invasive technology in diagnostic imaging, therapy, and targeted gene and drug delivery. As UTMC advances toward clinical translation, understanding its impact on fundamental cellular functions is essential.
Recent Findings: Recent studies on UTMC have provided insights into its effects on biological processes. These include transient membrane opening and resealing (sonoporation), calcium ion (Ca <sup>2+</sup> ) influx, generation of free radicals, nitric oxide synthesis, cytoskeletal remodeling, inter-endothelial gap formation, gene expression changes, and neuroinflammation. This review explores the mechanisms underlying UTMC, with a focus on ultrasound-targeted microbubble cavitation and its bioeffects on cellular function. We examine the molecular processes induced by cavitation, including sonoporation and Ca <sup>2+</sup> influx, and highlight their effects on key biological processes.
(© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Compliance with Ethical Standards. Conflict of interest: The authors declare that they have no conflict of interest. Human and Animal Rights and Informed Consent: This article does not contain any studies with human or animal subjects performed by any of the authors.