• Estimation of the Intracranial...

Treffer: Estimation of the Intracranial Volume Is Crucial in Multi-Site Studies: Reliability for Longitudinal Investigations and Traveling Subjects.

Title:
Estimation of the Intracranial Volume Is Crucial in Multi-Site Studies: Reliability for Longitudinal Investigations and Traveling Subjects.
Authors:
Koike S; Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, The University of Tokyo, Tokyo, Japan.; Institute for Diversity & Adaptation of Human Mind (UTIDAHM), University of Tokyo, Tokyo, Japan.; The International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo, Institutes for Advanced Study (UTIAS), Tokyo, Japan., Maikusa N; Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, The University of Tokyo, Tokyo, Japan., Cai L; Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, The University of Tokyo, Tokyo, Japan.; Division of Information Science, Nara Institute of Science and Technology, Nara, Japan., Ueda I; Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, The University of Tokyo, Tokyo, Japan., Shibukawa S; Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, The University of Tokyo, Tokyo, Japan.; Faculty of Health Science, Department of Radiological Technology, Juntendo University, Tokyo, Japan., Aso T; Laboratory for Brain Connectomics Imaging, RIKEN Center for Biosystems Dynamics Research, Hyogo, Japan., Tanaka SC; Division of Information Science, Nara Institute of Science and Technology, Nara, Japan.; Brain Information Communication Research Laboratory Group, Advanced Telecommunications Research Institute International, Kyoto, Japan., Hayashi T; Faculty of Health Science, Department of Radiological Technology, Juntendo University, Tokyo, Japan.; Department of Brain Connectomics, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Corporate Authors:
Japanese Strategic Research Program for the Promotion of Brain Science (SRPBS) DecNef Study Project Group, Brain/MINDS Beyond Human Brain MRI (BMB‐HBM) Study Project Group
Source:
Human brain mapping [Hum Brain Mapp] 2025 Nov; Vol. 46 (16), pp. e70405.
Publication Type:
Journal Article; Multicenter Study
Language:
English
Journal Info:
Publisher: Wiley Country of Publication: United States NLM ID: 9419065 Publication Model: Print Cited Medium: Internet ISSN: 1097-0193 (Electronic) Linking ISSN: 10659471 NLM ISO Abbreviation: Hum Brain Mapp Subsets: MEDLINE
Imprint Name(s):
Publication: New York : Wiley
Original Publication: New York : Wiley-Liss, c1993-
MeSH Terms:
Magnetic Resonance Imaging*/standards , Magnetic Resonance Imaging*/methods , Brain*/anatomy & histology , Brain*/diagnostic imaging , Neuroimaging*/standards , Neuroimaging*/methods , Image Processing, Computer-Assisted*/standards , Image Processing, Computer-Assisted*/methods, Humans ; Male ; Female ; Reproducibility of Results ; Adult ; Longitudinal Studies ; Young Adult ; Middle Aged ; Adolescent ; Japan ; Aged
References:
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Grant Information:
JPMJMS2021 Japan Science and Technology Agency; JP23H03877 Japan Society for the Promotion of Science; JP24K02378 Japan Society for the Promotion of Science; JP23tm0524002 Japan Agency for Medical Research and Development; JP24wm0625302 Japan Agency for Medical Research and Development; International Research Center for Neurointelligence (WPI-IRCN)
Entry Date(s):
Date Created: 20251105 Date Completed: 20251105 Latest Revision: 20251203
Update Code:
20251203
PubMed Central ID:
PMC12587433
DOI:
10.1002/hbm.70405
PMID:
41190774
Database:
MEDLINE

Weitere Informationen

Accurate estimation of the total intracranial volume (TIV) is essential in brain magnetic resonance imaging (MRI) studies, particularly for multi-site longitudinal investigations. This study assessed the validity and reliability of segmentation-based TIV (sbTIV) implemented in FreeSurfer version 7.2 for large-scale multi-site MRI data, by comparing it with the widely used estimated TIV (eTIV). We analyzed 6524 structural MRI scans from two multi-site projects in Japan, consisting of 30 procedures across 21 sites, 13 MRI machine types, 3 vendors, and 4 protocol categories. We tested the intraclass correlation coefficients (ICCs) between eTIV and sbTIV for each procedure and identified procedural factors affecting these ICCs using a general linear model. Machine- and protocol-specific biases were considered by a traveling subject harmonization approach. To specifically examine the reliability and validity of the longitudinal scans, we employed a general linear mixed model (GLMM). Overall agreement between eTIV and sbTIV was good (ICC = 0.78) but varied across procedures (0.62-0.94). The 1.0 mm isotropic protocol showed the highest reliability. Notably, there was poor consistency in participants with eTIV values of 120,000 mm <sup>3</sup> or smaller (ICC = 0.053). sbTIV demonstrated superior cross-procedural consistency in adolescent and adult longitudinal scans compared to eTIV. In longitudinal scans, sbTIV showed greater sex difference and sex-specific increase for adolescents, and greater consistency for adults, compared to eTIV. sbTIV offers more robust and reliable estimation compared to eTIV, particularly for multi-site longitudinal studies. These findings highlight the need for careful consideration when interpreting previous multi-site studies using eTIV.
(© 2025 The Author(s). Human Brain Mapping published by Wiley Periodicals LLC.)