• Unveiling Dipolar Interaction-...

Treffer: Unveiling Dipolar Interaction-Driven Magnetic Field Inhomogeneities in T 2 MRI Contrast Agents.

Title:
Unveiling Dipolar Interaction-Driven Magnetic Field Inhomogeneities in T 2 MRI Contrast Agents.
Authors:
García-Acevedo P; NANOMAG Laboratory, Applied Physics Department, iMATUS Materials Institute and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, 15782, Spain.; Neuroimaging and Biotechnology Laboratory (NOBEL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, 15706, Spain.; Advanced (magnetic) Theranostic Nanostructures Lab, International Iberian Nanotechnology Laboratory, Braga, 4715-330, Portugal., Piñeiro Y; NANOMAG Laboratory, Applied Physics Department, iMATUS Materials Institute and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, 15782, Spain., Gallo J; Advanced (magnetic) Theranostic Nanostructures Lab, International Iberian Nanotechnology Laboratory, Braga, 4715-330, Portugal., Ramos-Cabrer P; Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Donostia-San Sebastián, 20014, Spain., Iglesias-Rey R; Neuroimaging and Biotechnology Laboratory (NOBEL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, 15706, Spain., Rivas J; NANOMAG Laboratory, Applied Physics Department, iMATUS Materials Institute and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, 15782, Spain., Bañobre-López M; Advanced (magnetic) Theranostic Nanostructures Lab, International Iberian Nanotechnology Laboratory, Braga, 4715-330, Portugal.
Source:
Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2026 Jan; Vol. 13 (3), pp. e10356. Date of Electronic Publication: 2025 Nov 04.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE
Imprint Name(s):
Original Publication: Weinheim : WILEY-VCH, [2014]-
MeSH Terms:
Magnetic Resonance Imaging*/methods , Contrast Media*/chemistry , Magnetic Fields*, Ferric Compounds/chemistry ; Magnetite Nanoparticles/chemistry
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Grant Information:
IN606B-2024.1 Axencia Galega de Innovación; 0072_IBEROS_MAIS_1_E Interreg-POCTEP 2021-2027; PLEC2022-009217 Ministerio de Ciencia e Innovación; CP22/00061 Instituto de Salud Carlos III; PLEC2022-009217 NextGenerationEU
Contributed Indexing:
Keywords: contrast agents; dipolar interactions; magnetic nanoparticles; magnetic resonance imaging; ultra‐high field‐MRI
Substance Nomenclature:
0 (Contrast Media)
0 (Ferric Compounds)
0 (Magnetite Nanoparticles)
Entry Date(s):
Date Created: 20251104 Date Completed: 20260115 Latest Revision: 20260117
Update Code:
20260117
PubMed Central ID:
PMC12806336
DOI:
10.1002/advs.202510356
PMID:
41186103
Database:
MEDLINE

Weitere Informationen

Modulating local magnetic field inhomogeneities, combined with ultra-high-field MRI (UHF-MRI) is a promising strategy to enhance the performance of next-generation T <subscript>2</subscript> contrast agents (CAs). Although dipolar interactions likely contribute to contrast enhancement, their role in magnetic inhomogeneities and proton dephasing remains poorly understood, limiting further optimization. In this study, the fundamental role of dipolar interactions on the modulation of the transverse relaxivity (r <subscript>2</subscript> ) of iron oxide-based CAs is demonstrated by shaping local magnetic field inhomogeneities. A nanoscale-distance-tuned model system is developed by coating superparamagnetic iron oxide nanoprobes with silica shells of increasing thickness, thereby modulating the intensity of the dipolar interactions. An exponential dependence of r <subscript>2</subscript> on dipolar interaction strength is observed, with a sharp initial increase followed by a plateau as interactions reached their effective range, resulting in up to a sevenfold enhancement compared to interaction-free CAs. Furthermore, the dependence of r <subscript>2</subscript> on B <subscript>0</subscript> is evaluated across conventional field-MRI (1.4 and 3.0 T) to UHF-MRI (7.0 and 11.7 T), in both interacting and non-interacting CA systems, revealing a nonlinear behavior. These findings establish dipolar interaction control as a key parameter for optimizing T <subscript>2</subscript> -CAs performance, advancing the design of next-generation MRI nanoprobes for diagnostic applications.
(© 2025 International Iberian Nanotechnology Laboratory and The Author(s). Advanced Science published by Wiley‐VCH GmbH.)