• Integrated Real-Time Therapy a...

Treffer: Integrated Real-Time Therapy and Monitor Study of a Dual-Frequency Focusing Transducer Based on Vibroacoustic Signals.

Title:
Integrated Real-Time Therapy and Monitor Study of a Dual-Frequency Focusing Transducer Based on Vibroacoustic Signals.
Authors:
Chen Z; State Key Laboratory of Ultrasound in Medicine and Engimeering, College of Biomedical Eingineering, Chongqing Medical University, Chonging 400016, China., Hu C; Equipment and Materials Department, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China., Ai X; State Key Laboratory of Ultrasound in Medicine and Engimeering, College of Biomedical Eingineering, Chongqing Medical University, Chonging 400016, China., Jiang F; State Key Laboratory of Ultrasound in Medicine and Engimeering, College of Biomedical Eingineering, Chongqing Medical University, Chonging 400016, China., Hu X; State Key Laboratory of Ultrasound in Medicine and Engimeering, College of Biomedical Eingineering, Chongqing Medical University, Chonging 400016, China., Song J; State Key Laboratory of Ultrasound in Medicine and Engimeering, College of Biomedical Eingineering, Chongqing Medical University, Chonging 400016, China., Tan P; State Key Laboratory of Ultrasound in Medicine and Engimeering, College of Biomedical Eingineering, Chongqing Medical University, Chonging 400016, China., Tan J; State Key Laboratory of Ultrasound in Medicine and Engimeering, College of Biomedical Eingineering, Chongqing Medical University, Chonging 400016, China., Li Y; State Key Laboratory of Ultrasound in Medicine and Engimeering, College of Biomedical Eingineering, Chongqing Medical University, Chonging 400016, China. Electronic address: liyanhao@cqmu.edu.cn.
Source:
Ultrasound in medicine & biology [Ultrasound Med Biol] 2026 Jan; Vol. 52 (1), pp. 149-158. Date of Electronic Publication: 2025 Oct 12.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Pergamon Press Country of Publication: England NLM ID: 0410553 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-291X (Electronic) Linking ISSN: 03015629 NLM ISO Abbreviation: Ultrasound Med Biol Subsets: MEDLINE
Imprint Name(s):
Original Publication: Oxford, New York, Pergamon Press.
MeSH Terms:
Transducers* , High-Intensity Focused Ultrasound Ablation*/instrumentation , High-Intensity Focused Ultrasound Ablation*/methods , Elasticity Imaging Techniques*/methods , Elasticity Imaging Techniques*/instrumentation, Animals ; Cattle ; Equipment Design ; Computer Systems ; Heart
Contributed Indexing:
Keywords: High-intensity focused ultrasound (HIFU); acoustic emission signal; dual-frequency HIFU system; temperature monitoring; vibration acoustic imaging
Entry Date(s):
Date Created: 20251012 Date Completed: 20251116 Latest Revision: 20251116
Update Code:
20251117
DOI:
10.1016/j.ultrasmedbio.2025.09.006
PMID:
41077494
Database:
MEDLINE

Weitere Informationen

Objective: Accurate temperature monitoring is crucial during High-Intensity Focused Ultrasound (HIFU) therapy to ensure both therapeutic efficacy and tissue safety. Traditional monitoring methods, such as MRI thermometry, are limited by high cost and poor real-time performance.
Methods: This paper proposes a novel temperature monitoring and control strategy based on Ultrasound-Stimulated Acoustic Emission (USAE) signals combined with Vibro-Acoustography (VA) technology to achieve real-time assessment of tissue temperature changes and damage status. Dual-frequency HIFU transducers were employed to achieve synchronous acquisition of dual-frequency confocal excitation and USAE signals. Validation experiments were successively conducted on a graphite model, ex vivo bovine heart tissue, and in vivo tissue.
Results: The results showed that both the USAE signal amplitude and temperature exhibited an increasing trend prior to tissue injury. The temperature in the low-temperature zone of the graphite model increased linearly over time, with a heating rate of approximately 0.65°C/s and a linear fit of R² = 0.98. The temperature rise rate in ex vivo bovine heart tissue increased significantly to 7.31°C/s (R² = 0.96). At the 4-second and 6-second marks, the predicted temperatures were 50.6°C and 65.2°C, respectively, both consistent with the measured values, indicating the strong predictive capability of the fitted model. Furthermore, results from all three experimental groups indicated that when tissue underwent thermal coagulation, the USAE signal amplitude decreased, and the rate of temperature change also reduced. Combined with VA imaging results, it was demonstrated that changes in USAE signals are highly consistent with the evolution of tissue structure.
Conclusion: This study demonstrates the application potential of a USAE signal-based temperature feedback mechanism in HIFU therapy, providing a theoretical foundation and experimental basis for constructing a real-time and non-invasive acoustic feedback system.
(Copyright © 2025 World Federation for Ultrasound in Medicine and Biology. Published by Elsevier Inc. All rights reserved.)

Conflict of interest The authors declare no conflict of interest.