• Optimized motion-insensitive P...

Treffer: Optimized motion-insensitive PDFF mapping of the liver.

Title:
Optimized motion-insensitive PDFF mapping of the liver.
Authors:
Tang J; Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA., Tamada D; Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA., do Vale Souza R; Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA., Faacks A; Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA., Starekova J; Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA., Heidenreich JF; Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany., Müller L; Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Diagnostic and Interventional Radiology, University Medical Center Mainz, Mainz, Germany., Fullerton GC; Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA., Buelo CJ; Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA., Kammerman J; Calimetrix, LLC, Madison, Wisconsin, USA., Brittain JH; Calimetrix, LLC, Madison, Wisconsin, USA., Reeder SB; Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Emergency Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA., Hernando D; Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Source:
Magnetic resonance in medicine [Magn Reson Med] 2026 Jan; Vol. 95 (1), pp. 249-267. Date of Electronic Publication: 2025 Sep 02.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Wiley Country of Publication: United States NLM ID: 8505245 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-2594 (Electronic) Linking ISSN: 07403194 NLM ISO Abbreviation: Magn Reson Med Subsets: MEDLINE
Imprint Name(s):
Publication: 1999- : New York, NY : Wiley
Original Publication: San Diego : Academic Press,
MeSH Terms:
Liver*/diagnostic imaging , Magnetic Resonance Imaging*/methods , Image Processing, Computer-Assisted*/methods , Adipose Tissue*/diagnostic imaging, Humans ; Phantoms, Imaging ; Artifacts ; Reproducibility of Results ; Adult ; Male ; Female ; Motion ; Prospective Studies ; Algorithms ; Signal-To-Noise Ratio ; Imaging, Three-Dimensional ; Image Interpretation, Computer-Assisted/methods ; Middle Aged
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Grant Information:
R01 EB031886 United States EB NIBIB NIH HHS; R44 EB025729 United States EB NIBIB NIH HHS; R01EB031886 United States EB NIBIB NIH HHS; R44EB025729 United States EB NIBIB NIH HHS; R01EB031886 United States EB NIBIB NIH HHS; R44EB025729 United States EB NIBIB NIH HHS
Contributed Indexing:
Keywords: MASLD; PDFF; fat quantification; liver; motion robustness; proton density fat fraction
Entry Date(s):
Date Created: 20250902 Date Completed: 20251116 Latest Revision: 20251119
Update Code:
20251119
PubMed Central ID:
PMC12490877
DOI:
10.1002/mrm.70047
PMID:
40891444
Database:
MEDLINE

Weitere Informationen

Purpose: To implement, optimize, and validate parallel imaging (PI)-accelerated, 2D, flip angle modulated (FAM) chemical shift-encoded quantification of liver proton-density fat fraction (PDFF), with motion insensitivity.
Methods: The optimization cost function that determines flip angles in FAM was generalized for PI. Phantom studies and prospective studies in volunteers with varying liver fat levels were performed. Free-breathing FAM was acquired in the axial, sagittal, and coronal planes, with varying nominal PI acceleration factors (R) of 1.0 to 3.0. A breath-held, commercially available 3D chemical shift-encoded method was acquired as reference for PDFF. Overall image quality, qualitative SNR, and motion artifacts for all methods were Likert-scale rated. PDFF measured by FAM was compared to reference to assess bias. Test-retest repeatability was assessed for all methods by repeating acquisitions after volunteer repositioning. Noise performance was assessed with standard deviation of PDFF maps as R increased.
Results: The reader study (N = 3 readers/10 subjects) demonstrated excellent image quality for FAM during free-breathing, with reduced motion artifacts compared to breath-held reference (p < 0.01). PI-accelerated FAM shows fewer motion artifacts than unaccelerated FAM (p < 0.01). In all planes and accelerations, PDFF measured by FAM showed good agreement with reference PDFF measurements (mean bias: -0.4% to 2.0% PDFF; 95% limits of agreement: 2.8% to 4.0% PDFF). FAM in axial and coronal planes showed similar or improved repeatability (repeatability coefficient = 1.7% to 2.6% PDFF) compared to the reference (2.7%). Sagittal FAM shows similar or worse repeatability (repeatability coefficient = 3.0% to 3.6%). FAM with R = 2.0 has good noise performance and high SNR efficiency.
Conclusion: FAM, in axial or coronal planes with R = 2.0, is optimal for motion-insensitive liver PDFF quantification.
(© 2025 The Author(s). Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.)