• Exploiting glycan arrays and b...

Treffer: Exploiting glycan arrays and biosensors to diagnose and understand diseases.

Title:
Exploiting glycan arrays and biosensors to diagnose and understand diseases.
Authors:
Lee AS; Graduate School of Chemical Engineering, Dongguk University, Seoul 04620, Republic of Korea., Heo HR; Department of Chemical and Biochemical Engineering, Dongguk University, Seoul 04620, Republic of Korea., Song YH; School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea., Kim CS; Graduate School of Chemical Engineering, Dongguk University, Seoul 04620, Republic of Korea; Department of Chemical and Biochemical Engineering, Dongguk University, Seoul 04620, Republic of Korea. Electronic address: biocskim@dgu.ac.kr., Seo JH; School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea. Electronic address: jhseo78@yu.ac.kr., Cha HJ; Department of Chemical Engineering, Pohang University of Science and Technology, Pohang 37673, Republic of Korea; Medical Science and Engineering, School of Convergence Science and Technology, Pohang University of Science and Technology, Pohang 37673, Republic of Korea. Electronic address: hjcha@postech.ac.kr.
Source:
Biotechnology advances [Biotechnol Adv] 2025 Oct; Vol. 83, pp. 108635. Date of Electronic Publication: 2025 Jun 28.
Publication Type:
Journal Article; Review
Language:
English
Journal Info:
Publisher: Elsevier Science Country of Publication: England NLM ID: 8403708 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1899 (Electronic) Linking ISSN: 07349750 NLM ISO Abbreviation: Biotechnol Adv Subsets: MEDLINE
Imprint Name(s):
Publication: Oxford : Elsevier Science
Original Publication: Oxford ; New York : Pergamon Press, c1983-
MeSH Terms:
Polysaccharides*/chemistry , Polysaccharides*/metabolism , Polysaccharides*/analysis , Biosensing Techniques*/methods , Microarray Analysis*/methods, Humans ; Neoplasms/diagnosis ; Neoplasms/metabolism ; Glycosylation ; Animals
Contributed Indexing:
Keywords: Biomedical applications; Diseases; Glycan arrays; Glycan biosensors; Glycan immobilization; Glycan sources
Substance Nomenclature:
0 (Polysaccharides)
Entry Date(s):
Date Created: 20250630 Date Completed: 20250807 Latest Revision: 20250807
Update Code:
20250808
DOI:
10.1016/j.biotechadv.2025.108635
PMID:
40588045
Database:
MEDLINE

Weitere Informationen

Aberrant glycosylation patterns, often observed in disease states compared to those in normal states, are involved in disease-related processes such as cancer cell development and metastasis. Analyzing glycan-associated interactions could provide promising avenues for disease detection and therapeutic development. Over the past two decades, glycan arrays and biosensors have become powerful analytical tools for characterizing glycan-associated interactions, screening functional glycans, and detecting glycan-related diseases. This review aims to describe glycan source preparation and immobilization methods used to construct glycan arrays and biosensors. We summarize methods for obtaining glycans from natural sources and for chemical and enzymatic synthesis. In particular, we cover a method of immobilizing DNA, proteins, and lipids that mimic cell-surface glycoconjugates. Finally, we discuss the biomedical applications of glycan arrays and biosensors, including identification of cancer-specific glycan biomarkers, evaluation of glycan-induced antibody responses in cancer, cancer detection, analysis of glycan-binding specificities of pathogens and their toxins, pathogen detection, and drug discovery.
(Copyright © 2025 Elsevier Inc. All rights reserved.)

Declaration of competing interest All authors declare that there are no competing interests.