• Innervating 3D in vitro models...

Treffer: Innervating 3D in vitro models: bioengineering and design blueprints.

Title:
Innervating 3D in vitro models: bioengineering and design blueprints.
Authors:
de Carvalho MT; Department of Chemistry, Centre for Research in Ceramics and Composite Materials (CICECO)-Aveiro Institute of Materials, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal; Cellularis Biomodels, Parque de Ciência e Inovação (PCI) Creative Science Park, Aveiro Region, Via do Conhecimento, 3830-352 Ílhavo, Portugal., Henriques-Pereira M; Department of Chemistry, Centre for Research in Ceramics and Composite Materials (CICECO)-Aveiro Institute of Materials, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal; Cellularis Biomodels, Parque de Ciência e Inovação (PCI) Creative Science Park, Aveiro Region, Via do Conhecimento, 3830-352 Ílhavo, Portugal., Monteiro MV; Department of Chemistry, Centre for Research in Ceramics and Composite Materials (CICECO)-Aveiro Institute of Materials, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal; Cellularis Biomodels, Parque de Ciência e Inovação (PCI) Creative Science Park, Aveiro Region, Via do Conhecimento, 3830-352 Ílhavo, Portugal., Lamghari M; Instituto de Inovação e Investigação em Saúde (i3S), Rua Alfredo Allen 208, 4200-135 Porto, Portugal., Mano JF; Department of Chemistry, Centre for Research in Ceramics and Composite Materials (CICECO)-Aveiro Institute of Materials, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal; Cellularis Biomodels, Parque de Ciência e Inovação (PCI) Creative Science Park, Aveiro Region, Via do Conhecimento, 3830-352 Ílhavo, Portugal. Electronic address: jmano@ua.pt., Gaspar VM; Department of Chemistry, Centre for Research in Ceramics and Composite Materials (CICECO)-Aveiro Institute of Materials, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal; Cellularis Biomodels, Parque de Ciência e Inovação (PCI) Creative Science Park, Aveiro Region, Via do Conhecimento, 3830-352 Ílhavo, Portugal. Electronic address: vm.gaspar@ua.pt.
Source:
Trends in biotechnology [Trends Biotechnol] 2025 Nov; Vol. 43 (11), pp. 2743-2758. Date of Electronic Publication: 2025 Jun 13.
Publication Type:
Journal Article; Review
Language:
English
Journal Info:
Publisher: Elsevier Science Publishers Country of Publication: England NLM ID: 8310903 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3096 (Electronic) Linking ISSN: 01677799 NLM ISO Abbreviation: Trends Biotechnol Subsets: MEDLINE
Imprint Name(s):
Publication: Barking : Elsevier Science Publishers
Original Publication: [Amsterdam, Netherlands : Elsevier Science Publishers B.V. (Biomedical Division), c1983-
MeSH Terms:
Bioengineering*/methods , Tissue Engineering*/methods , Models, Biological*, Humans ; Animals
Contributed Indexing:
Keywords: 3D in vitro models; bioengineering; cancer; innervation; tissue regeneration
Entry Date(s):
Date Created: 20250614 Date Completed: 20251112 Latest Revision: 20251112
Update Code:
20251112
DOI:
10.1016/j.tibtech.2025.05.012
PMID:
40517115
Database:
MEDLINE

Weitere Informationen

Innervation plays a key role in tissue homeostasis, disease, and repair throughout our lifetimes. Strategies for emulating innervation and its bioinstructive influence on surrounding cells are thus highly desirable to upgrade the organotypic features of human in vitro models. We delve into the latest strategies for generating innervated 3D models that mimic native innervation patterns, and highlight recent advances in bioengineering living platforms for emulating the effect of innervation during tissue regeneration or for recapitulating tumor-nerve interplay. We present an overview of the key design blueprints for generating innervated tissue models, highlight the challenges to be overcome, and discuss the biomedical breakthroughs that can branch from such in vitro platforms.
(Copyright © 2025 Elsevier Ltd. All rights reserved.)

Declaration of interests J.F.M. and V.M. are cofounders of the Cellularis Biomodels company, and J.F.M. is a cofounder of the Metatissue–Biosolutions company. The other authors declare no competing interests.