• Ultrasound contrast microbubbl...

Treffer: Ultrasound contrast microbubbles to predict the microsphere distribution during transarterial radioembolization with holmium microspheres, an in vitro proof of concept study.

Title:
Ultrasound contrast microbubbles to predict the microsphere distribution during transarterial radioembolization with holmium microspheres, an in vitro proof of concept study.
Authors:
van der Hoek JL; Multi-Modality Medical Imaging Group, TechMed Center, University of Twente, Enschede, The Netherlands., Snoeijink TJ; Multi-Modality Medical Imaging Group, TechMed Center, University of Twente, Enschede, The Netherlands.; Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands., Mirgolbabaee H; Multi-Modality Medical Imaging Group, TechMed Center, University of Twente, Enschede, The Netherlands.; Physics of Fluids Group, TechMed Center, University of Twente, Enschede, The Netherlands., Kunst R; Multi-Modality Medical Imaging Group, TechMed Center, University of Twente, Enschede, The Netherlands., Versluis M; Physics of Fluids Group, TechMed Center, University of Twente, Enschede, The Netherlands., Arens J; Engineering Organ Support Technologies Group, Department of Biomechanical Engineering, University of Twente, Enschede, The Netherlands., Manohar S; Multi-Modality Medical Imaging Group, TechMed Center, University of Twente, Enschede, The Netherlands., Groot Jebbink E; Multi-Modality Medical Imaging Group, TechMed Center, University of Twente, Enschede, The Netherlands.
Source:
Drug delivery [Drug Deliv] 2025 Dec; Vol. 32 (1), pp. 2505007. Date of Electronic Publication: 2025 May 18.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Taylor & Francis Country of Publication: England NLM ID: 9417471 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0464 (Electronic) Linking ISSN: 10717544 NLM ISO Abbreviation: Drug Deliv Subsets: MEDLINE
Imprint Name(s):
Publication: 2015->: Abingdon, Oxford : Taylor & Francis
Original Publication: Orlando, FL : Academic Press, c1993-
MeSH Terms:
Microspheres* , Microbubbles* , Holmium*/administration & dosage , Holmium*/chemistry , Contrast Media*/chemistry , Contrast Media*/administration & dosage , Embolization, Therapeutic*/methods, Tissue Distribution ; Ultrasonography/methods ; Liver Neoplasms/therapy ; Hepatic Artery/metabolism ; Phantoms, Imaging ; Proof of Concept Study ; Liver/metabolism
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Contributed Indexing:
Keywords: In-vitro model; biodistribution; holmium microspheres; particle flow behavior; transarterial radioembolization; ultrasound contrast microbubbles
Substance Nomenclature:
W1XX32SQN1 (Holmium)
0 (Contrast Media)
Entry Date(s):
Date Created: 20250519 Date Completed: 20250519 Latest Revision: 20250522
Update Code:
20250522
PubMed Central ID:
PMC12090288
DOI:
10.1080/10717544.2025.2505007
PMID:
40384014
Database:
MEDLINE

Weitere Informationen

Transarterial radioembolization (TARE) is an established treatment method for non-resectable liver tumors. One of the challenges of the approach is the accurate prediction of the microsphere biodistribution in the liver. We propose to use ultrasound contrast microbubbles as holmium microsphere precursors, which allows real-time prediction of the microsphere trajectories and biodistribution using dynamic contrast-enhanced ultrasound (DCE-US). The immediate goal in this in vitro study was to investigate the predictive capabilities of microbubbles as microsphere precursors. The study was conducted in an experimental in vitro model which represents the bifurcating right branch of the hepatic artery. A controlled injection of experimental BR-14 ultrasound contrast microbubbles and non-radioactive holmium-165 microspheres was performed in separate consecutive experiments in an arterial flow phantom. The microbubbles and microspheres were collected separately at the outlets of the phantom and counted using a Coulter counter to determine their distribution over the different outlets. The flow profile, the injection velocity, and the catheter position were monitored during the measurements to ensure stability. The results showed a good correlation between the microbubble and the microsphere distributions (p = 0.0038, r = 0.88) measured at the outlets. Differences in the distributions could be attributed to the characteristics of microbubbles and microspheres alone (e.g. particle size and concentration), since critical parameters were kept stable between the two experiments. The current in vitro study provides confidence that the microsphere biodistribution can be predicted using contrast microbubbles. The comparison provided by this study forms a foundation for the development of a DCE-US guided TARE treatment.