Treffer: Bioengineering Innervated Esophagus With Improved Motility: Limitations and Future Directions.
Title:
Bioengineering Innervated Esophagus With Improved Motility: Limitations and Future Directions.
Authors:
Wanczyk H; Department of Pediatrics, University of Connecticut Health Center, Farmington, Connecticut, USA., Walker J; Department of Pediatrics, University of Connecticut Health Center, Farmington, Connecticut, USA., Goldstein AM; Department of Pediatric Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA., Finck C; Department of Pediatrics, University of Connecticut Health Center, Farmington, Connecticut, USA.; Department of Surgery, Connecticut Children's Medical Center, Hartford, Connecticut, USA.
Source:
Neurogastroenterology and motility [Neurogastroenterol Motil] 2025 Nov; Vol. 37 (11), pp. e70074. Date of Electronic Publication: 2025 May 15.
Publication Type:
Journal Article; Review
Language:
English
Journal Info:
Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 9432572 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2982 (Electronic) Linking ISSN: 13501925 NLM ISO Abbreviation: Neurogastroenterol Motil Subsets: MEDLINE
Imprint Name(s):
Original Publication: Osney Mead, Oxford, UK : Blackwell Scientific Publications, c1994-
MeSH Terms:
References:
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Contributed Indexing:
Keywords: enteric neural stem cells; innervation; motility; peristalsis; smooth muscle cells; tissue engineered esophagus
Entry Date(s):
Date Created: 20250516 Date Completed: 20251018 Latest Revision: 20251018
Update Code:
20251018
DOI:
10.1111/nmo.70074
PMID:
40375568
Database:
MEDLINE
Weitere Informationen
Background: Over the past decade, research involving the bioengineering of esophageal tissue replacements for repair of congenital defects, cancer, and caustic injuries has advanced rapidly. This is due to the development of innovative biomaterials combined with stem cells that recapitulate tissue ultrastructure, mechanics, and biochemical properties. However, a limitation in the field is a lack of data demonstrating development of innervated tissue exhibiting peristalsis. Currently, no clinically available stem cell therapies/esophageal tissue substitutes exist that restore motility.
Purpose: This review will discuss advances and limitations in the assessment of esophageal motility in bioengineered tissues along with metrics of success. Additionally, innovative technologies (i.e., 3D bioprinting, electrospinning, and AI) and neuronal cellular approaches for promoting gut innervation will be highlighted to reveal their use for the development of clinical therapies for esophageal replacement. Future directions for development of patient-specific implants will also be discussed to emphasize the importance of access to all populations.
(© 2025 John Wiley & Sons Ltd.)