• Surgical Bioengineering of the...

Treffer: Surgical Bioengineering of the Microvasculature and Challenges in Clinical Translation.

Title:
Surgical Bioengineering of the Microvasculature and Challenges in Clinical Translation.
Authors:
Schlidt K; Zubar Plastic Surgery Research Laboratory, Department of Surgery, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA., Asgardoon M; Zubar Plastic Surgery Research Laboratory, Department of Surgery, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA., Febre-Alemañy DA; Zubar Plastic Surgery Research Laboratory, Department of Surgery, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA., El-Mallah JC; Zubar Plastic Surgery Research Laboratory, Department of Surgery, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA., Waldron O; Zubar Plastic Surgery Research Laboratory, Department of Surgery, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA., Dawes J; Zubar Plastic Surgery Research Laboratory, Department of Surgery, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA., Agrawal S; Zubar Plastic Surgery Research Laboratory, Department of Surgery, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA., Landmesser ME; Zubar Plastic Surgery Research Laboratory, Department of Surgery, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA., Ravnic DJ; Zubar Plastic Surgery Research Laboratory, Department of Surgery, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.; Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
Source:
Tissue engineering. Part B, Reviews [Tissue Eng Part B Rev] 2025 Dec; Vol. 31 (6), pp. 566-588. Date of Electronic Publication: 2025 Apr 02.
Publication Type:
Journal Article; Review
Language:
English
Journal Info:
Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101466660 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-3376 (Electronic) Linking ISSN: 19373368 NLM ISO Abbreviation: Tissue Eng Part B Rev Subsets: MEDLINE
Imprint Name(s):
Original Publication: New Rochelle, NY : Mary Ann Liebert, Inc.
MeSH Terms:
Tissue Engineering*/methods , Microvessels*/physiology , Microvessels*/surgery , Translational Research, Biomedical* , Neovascularization, Physiologic* , Bioengineering*/methods, Humans ; Animals ; Tissue Scaffolds/chemistry
Contributed Indexing:
Keywords: bioengineering; flap; graft; microvasculature; surgery; transplant
Entry Date(s):
Date Created: 20250402 Date Completed: 20251128 Latest Revision: 20251128
Update Code:
20251128
DOI:
10.1089/ten.teb.2024.0242
PMID:
40171780
Database:
MEDLINE

Weitere Informationen

Tissue and organ dysfunction are major causes of worldwide morbidity and mortality with all medical specialties being impacted. Tissue engineering is an interdisciplinary field relying on the combination of scaffolds, cells, and biologically active molecules to restore form and function. However, clinical translation is still largely hampered by limitations in vascularization. Consequently, a thorough understanding of the microvasculature is warranted. This review provides an overview of (1) angiogenesis, including sprouting angiogenesis, intussusceptive angiogenesis, vascular remodeling, vascular co-option, and inosculation; (2) strategies for vascularized engineered tissue fabrication such as scaffold modulation, prevascularization, growth factor utilization, and cell-based approaches; (3) guided microvascular development via scaffold modulation with electromechanical cues, 3D bioprinting, and electrospinning; (4) surgical approaches to bridge the micro- and macrovasculatures in order to hasten perfusion; and (5) building specific vasculature in the context of tissue repair and organ transplantation, including skin, adipose, bone, liver, kidney, and lung. Our goal is to provide the reader with a translational overview that spans developmental biology, tissue engineering, and clinical surgery.