Treffer: Bioengineering and omics approaches for Type 1 diabetes practical research: advancements and constraints.
Title:
Bioengineering and omics approaches for Type 1 diabetes practical research: advancements and constraints.
Authors:
Peng X; Department of Endocrinology and Metabolism, Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College, Nanchong, Sichuan, China.; Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan, China., Li L; Department of Endocrinology and Metabolism, Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College, Nanchong, Sichuan, China., Peng Y; Department of Endocrinology and Metabolism, Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College, Nanchong, Sichuan, China., Zhou G; Department of Endocrinology and Metabolism, Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College, Nanchong, Sichuan, China., An Z; Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Source:
Annals of medicine [Ann Med] 2025 Dec; Vol. 57 (1), pp. 2322047. Date of Electronic Publication: 2024 Dec 20.
Publication Type:
Journal Article; Review
Language:
English
Journal Info:
Publisher: Informa Healthcare Country of Publication: England NLM ID: 8906388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2060 (Electronic) Linking ISSN: 07853890 NLM ISO Abbreviation: Ann Med Subsets: MEDLINE
Imprint Name(s):
Publication: London : Informa Healthcare
Original Publication: Helsinki : Finnish Medical Society Duodecim, 1989-
Original Publication: Helsinki : Finnish Medical Society Duodecim, 1989-
MeSH Terms:
Diabetes Mellitus, Type 1*/genetics , Diabetes Mellitus, Type 1*/therapy , Diabetes Mellitus, Type 1*/immunology , Bioengineering*/methods, Humans ; Animals ; Genomics/methods ; Insulin-Secreting Cells/metabolism ; Proteomics/methods ; Insulin/metabolism ; Insulin/genetics ; Insulin/therapeutic use ; Islets of Langerhans/metabolism ; Islets of Langerhans/immunology
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Sci Rep. 2017 Nov 6;7(1):14620. (PMID: 29097671)
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Biomed Mater. 2023 Feb 17;18(2):. (PMID: 36720168)
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Clin Immunol. 2022 Nov;244:109118. (PMID: 36084852)
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Biomaterials. 2022 Jul;286:121566. (PMID: 35633590)
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Curr Opin Endocrinol Diabetes Obes. 2015 Aug;22(4):290-5. (PMID: 26087339)
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Adv Ther (Weinh). 2022 Sep;5(9):. (PMID: 36405778)
Clin Chim Acta. 2023 Jan 15;539:250-258. (PMID: 36584766)
JCI Insight. 2020 Apr 23;5(8):. (PMID: 32324170)
Lancet. 2023 Jun 24;401(10394):2149-2162. (PMID: 37030316)
Cell Rep. 2020 Aug 25;32(8):108067. (PMID: 32846125)
Nat Biotechnol. 2021 Jan;39(1):13-17. (PMID: 33384458)
Nat Biotechnol. 2015 May;33(5):518-23. (PMID: 25893782)
Proc Natl Acad Sci U S A. 2022 Jun 28;119(26):e2201267119. (PMID: 35733248)
Biomaterials. 2011 Apr;32(12):3233-43. (PMID: 21296410)
An Acad Bras Cienc. 2021 Jun 28;93(2):e20190942. (PMID: 34190843)
Diabetologia. 2020 Aug;63(8):1564-1575. (PMID: 32424539)
Nat Biotechnol. 2020 Apr;38(4):460-470. (PMID: 32094658)
BMB Rep. 2023 Jan;56(1):1. (PMID: 36698280)
Gastroenterology. 2021 Feb;160(3):875-888.e11. (PMID: 33121946)
Exp Cell Res. 2021 Aug 15;405(2):112667. (PMID: 34107273)
PLoS One. 2021 Oct 28;16(10):e0259043. (PMID: 34710142)
ACS Biomater Sci Eng. 2020 Jul 13;6(7):4155-4165. (PMID: 33463310)
Biomed Mater. 2023 Feb 03;18(2):. (PMID: 36599165)
Biomaterials. 2022 Feb;281:121342. (PMID: 34995903)
Nat Commun. 2020 Jun 29;11(1):3265. (PMID: 32601271)
Biochemistry (Mosc). 2003 Aug;68(8):926-33. (PMID: 12948394)
Anal Chem. 2019 Jul 2;91(13):8667-8675. (PMID: 31181164)
Diabetes Metab Res Rev. 2012 Oct;28(7):608-17. (PMID: 22585677)
Diabetes. 2012 Jul;61(7):1742-51. (PMID: 22537941)
Biomaterials. 2013 Sep;34(28):6760-72. (PMID: 23787110)
EMBO Mol Med. 2021 Jan 11;13(1):e12616. (PMID: 33135383)
Contributed Indexing:
Keywords: Bioengineering; in vitro models; omics; type 1 diabetes
Substance Nomenclature:
0 (Insulin)
Entry Date(s):
Date Created: 20241220 Date Completed: 20241220 Latest Revision: 20250108
Update Code:
20250114
PubMed Central ID:
PMC11703378
DOI:
10.1080/07853890.2024.2322047
PMID:
39704022
Database:
MEDLINE
Weitere Informationen
Insulin dependency arises from autoimmunity that targets the β cells of the pancreas, resulting in Type 1 diabetes (T1D). Despite the fact that T1D patients require insulin for survival, insulin does not provide a cure for this disease or prevent its complications. Despite extensive genetic, molecular, and cellular research on T1D over the years, the translation of this understanding into effective clinical therapies continues to pose a significant obstacle. It is therefore difficult to develop effective clinical treatment strategies without a thorough understanding of disease pathophysiology. Pancreatic tissue bioengineering models of human T1D offer a valuable approach to examining and controlling islet function while tackling various facets of the condition. And in recent years, due to advances in high-throughput omics analysis, the genotypic and molecular profiles of T1D have become finer tuned. The present article will examine recent progress in these areas, along with their utilization and constraints in the realm of T1D.