• Why are RNA processing factors...

Treffer: Why are RNA processing factors recruited to DNA double-strand breaks?

Title:
Why are RNA processing factors recruited to DNA double-strand breaks?
Authors:
Machour FE; Department of Biology, Technion - Israel Institute of Technology, Haifa 3200003, Israel., Barisaac AS; Department of Biology, Technion - Israel Institute of Technology, Haifa 3200003, Israel., Ayoub N; Department of Biology, Technion - Israel Institute of Technology, Haifa 3200003, Israel. Electronic address: ayoubn@technion.ac.il.
Source:
Trends in genetics : TIG [Trends Genet] 2025 Mar; Vol. 41 (3), pp. 194-200. Date of Electronic Publication: 2024 Nov 19.
Publication Type:
Journal Article; Review
Language:
English
Journal Info:
Publisher: Elsevier Trends Journals Country of Publication: England NLM ID: 8507085 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0168-9525 (Print) Linking ISSN: 01689525 NLM ISO Abbreviation: Trends Genet Subsets: MEDLINE
Imprint Name(s):
Publication: Cambridge : Elsevier Trends Journals
Original Publication: [Amsterdam, The Netherlands : Elsevier Science Publishers B.V., c1985-
MeSH Terms:
DNA Breaks, Double-Stranded* , DNA Repair*/genetics , RNA Processing, Post-Transcriptional*/genetics , RNA Splicing Factors*/genetics , RNA Splicing Factors*/metabolism, Humans ; Chromatin/genetics ; Protein Processing, Post-Translational/genetics ; Animals
Contributed Indexing:
Keywords: D compartment; DNA damage response (DDR); DNA double-strand break (DSB); RNA processing; chromatin organization
Substance Nomenclature:
0 (Chromatin)
0 (RNA Splicing Factors)
Entry Date(s):
Date Created: 20241120 Date Completed: 20250425 Latest Revision: 20250425
Update Code:
20250426
DOI:
10.1016/j.tig.2024.10.008
PMID:
39567312
Database:
MEDLINE

Weitere Informationen

DNA double-strand break (DSB) induction leads to local transcriptional silencing at damage sites, raising the question: Why are RNA processing factors (RPFs), including splicing factors, rapidly recruited to these sites? Recent findings show that DSBs cluster in a chromatin compartment termed the 'D compartment', where DNA damage response (DDR) genes relocate and undergo transcriptional activation. Here, we propose two non-mutually exclusive models to elucidate the rationale behind the recruitment of RPFs to DSB sites. First, RPFs circulate through the D compartment to process transcripts of the relocated DDR genes. Second, the D compartment serves as a 'post-translational modifications (PTMs) hub', altering RPF activity and leading to the production of unique DNA damage-induced transcripts, which are essential for orchestrating the DDR.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)

Declaration of interests The authors declare no competing interests.