Treffer: Prenatal and Childhood Phthalate Mixtures and Adolescent Sleep Health in the HOME Study.

BACKGROUND: The biological mechanisms linking early life phthalate exposure with adverse behaviors and cardiometabolic conditions also impact sleep health, but whether early life exposure impacts adolescent sleep is unknown. OBJECTIVES: We evaluated whether gestational and childhood urinary phthalate metabolite mixtures were associated with sleep characteristics during adolescence. We also examined periods of heightened susceptibility to individual phthalates. METHODS: In the Health Outcomes and Measures of the Environment (HOME) Study (Cincinnati, Ohio; 2003-2006; 푛=156), we quantified urinary metabolites of eight parent phthalate diesters during pregnancy (16- and 26-wk) and childhood (ages 1, 2, 3, 4, 5, 8, and 12 years). Using regression calibration approaches, we estimated average measurement error-corrected phthalate metabolite concentrations during pregnancy and childhood. We used wrist actigraphy to assess sleep characteristics for 1 wk among participants at age 12. Using quantile-based g-computation, we estimated covariate-adjusted differences in sleep efficiency (%), sleep fragmentation index scores (%), sleep duration (minutes) per quartile increase in all phthalate metabolite concentrations (ψ), and weights indicating the contribution of each metabolite to ψ. Using multiple informant models, we examined whether associations between individual phthalate metabolites and sleep characteristics varied by timing of exposure. RESULTS: Increasing all gestational phthalate metabolites by a quartile was associated with lower sleep efficiency [ψ=-1.3%; 95% confidence interval (CI): -2.4, -0.3] and higher sleep fragmentation (ψ=1.6%; 95% CI: 0.3, 3.0); mono-n-butyl phthalate (MnBP) and di(2-ethylhexyl) phthalate (DEHP) metabolites contributed most to these relations. Higher childhood phthalate metabolite mixture quartiles were associated with shorter sleep duration (ψ=-21 minutes; 95% CI: -34, -9); monoethyl phthalate (MEP) and monocarboxyoctyl phthalate (MCOP) contributed most to this association. We found that higher DEHP metabolite concentrations during pregnancy were more strongly related to higher sleep fragmentation than childhood concentrations. In contrast, higher MEP and MnBP concentrations during childhood, but not pregnancy, were consistently associated with shorter sleep duration. DISCUSSION: Phthalate metabolite concentrations during pregnancy and childhood were associated with poorer adolescent sleep health. [ABSTRACT FROM AUTHOR]

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